July 22 2021
NRG Oncology Plenary Session with Keynote Speaker Dr. Philip E. Castle
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July 13 2021
Pathology and Biospecimen Tips for Success
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June 28 2021
Quynh Le, MD Appointed as an NRG Oncology Group Chair
We are pleased to announce that Quynh-Thu Le, MD, from Stanford University, will serve as one of our three Group Chairs effective July 1, 2021. Read more
June 16 2021
Navigating the Virtual NRG Oncology Group Meeting
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June 16 2021
NRG Oncology GI Committee members appointees to NCI Task Forces
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June 16 2021
Investigating Deintensification of Head and Neck Radiation within NRG Oncology
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June 16 2021
FORTE Coming Soon!
Five- or Ten-Year Colonoscopy for 1-2 Non-Advanced Adenomatous Polyps Read more
June 16 2021
Recently Activated! NRG-BR007: The DEBRA Trial
Testing Hormonal Therapy Following Lumpectomy without Radiotherapy for Patients with Low-Risk, Early-Stage Breast Cancer (NRG-BR007: The DEBRA Trial) Read more
June 03 2021
OlympiA study results to be presented at 2021 ASCO Annual Meeting
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May 12 2021
Performance Status Measures - A Little History
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April 22 2021
NRG Oncology Study Shows Safety of Using Stereotactic Body Radiotherapy to Treat Multiple Metastases
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April 14 2021
Esophageal Cancer Awareness Month
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April 14 2021
Head and Neck Cancer Awareness Month
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April 14 2021
Acupuncture in Oncology
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March 09 2021
The Significance of Checkpoint Inhibitors and MMR/MSI Testing in Metastatic Colorectal Cancer (NRG-GI004/SWOG1610, the COMMIT Study)
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March 09 2021
Implementing Remote Consenting at the University of Hawaii Cancer Center, A Minority/Underserved NCORP Site
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March 09 2021
Comparing Hippocampal-Avoidant Whole Brain Radiotherapy to Stereotactic Radiosurgery for Patients with 10 or Fewer Brain Metastases from Small Cell Lung Cancer (NRG-CC009)
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March 09 2021
NRG Oncology Board of Directors Appoints New At-Large Director
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February 26 2021
NRG NCORP Solicits PILOT Projects for Applications: Biospecimens & Clinical Trial Data from Breast Cancer Prevention Studies
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February 23 2021
NRG Cancer Prevention Committee Seeks Applications for Chair of Committee
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February 19 2021
NSABP B-55/BIG 6-13 / OlympiA trial crossed superiority boundary for invasive disease-free survival vs. placebo at planned interim analysis
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February 19 2021
NRG Oncology NCORP solicits PILOT projects addressing NRG NCORP Health Disparities (HDC) Research priorities
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February 19 2021
NRG Oncology NCORP is soliciting PILOT projects for applications focused on NRG NCORP Cancer Prevention and Control (CPC) priorities
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February 19 2021
NRG Oncology NCORP solicits PILOT projects addressing NRG NCORP Cancer Care Delivery Research (CCDR) priorities
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February 18 2021
NRG Oncology’s Practice Changing Study on HA-WBRT plus Memantine Was Among Journal of Clinical Oncology’s Top 5 Downloads in 2020
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February 12 2021
The First Lady of the United States and NCI Leadership Highlight the Importance of NCORP on World Cancer Day
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February 11 2021
Recipe for Success for Quality of Life Questionnaire Study Compliance
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February 11 2021
NRG-CC008 Trial Now Open - February 2021 Newsletter
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February 11 2021
National Cancer Prevention Month - February 2021 Newsletter
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February 02 2021
NRG Oncology Appoints New Committee Chairs for Pathology and Health Disparities Research
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January 29 2021
The General Session at the NRG Winter 2021 Virtual Meeting
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January 29 2021
NRG NCORP Townhall at the NRG Winter 2021 Virtual Meeting
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January 29 2021
Reduced-Dose Radiation with Cisplatin Improves Outcomes for HPV-associated Oropharyngeal Carcinoma Patients on NRG Oncology Study, Justifies Phase III Trial
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January 29 2021
NRG Oncology Trial Results Show Safety of Adaptive Radiotherapy in Non-Small Cell Lung Cancer Patients, Open Paths to Future Prospective Studies
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January 28 2021
The NRG New Investigator Sessions at the NRG Winter 2021 Virtual Meeting
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January 20 2021
NRG Oncology Health Equity New Investigator Mentor Program for Underrepresented Minority Scholars
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January 19 2021
A Message from Drs. Norman Wolmark and Robert Mannel
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January 16 2021
NRG Oncology Study Determines Total Neoadjuvant Therapy with Pembrolizumab and Chemoradiotherapy is Safe, but May Not be Beneficial for Patients with Locally-Advanced Rectal Cancer
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January 12 2021
Keeping a Positive Attitude as a Cancer Research Nurse, Through a Global Pandemic
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January 12 2021
De-intensification and Intensification Treatments for High-Risk Prostate Cancer Patients Stratified by Genomic Risk (NRG-GU009)
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January 12 2021
Does the Addition of Hippocampal-Avoidant Whole Brain Radiotherapy and Memantine to Salvage Radiosurgery Prevent Neurologic Death for Patients with Recurrent Brain Metastases and High Brain Metastasis Velocity after Upfront Radiosurgery? (NRG-BN009)
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January 12 2021
2020 In Review: A Message from the Chairs of NRG Oncology’s Research Strategy Committee
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January 12 2021
NRG Oncology Elects Two Members to its Board of Directors
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December 15 2020
Updated Message from NRG Oncology Leadership on COVID-19
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December 14 2020
NRG Oncology Winter Holiday Hours
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December 11 2020
Adding Peposertib to Radiotherapy for Patients with Advanced Head and Neck Cancer Who are Cisplatin-Ineligible (NRG-HN008)
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November 10 2020
Unique Trial Combines Concurrent Immunotherapy and Radiation Therapy to Determine if this Treatment Option Improves Survival Outcomes for Patients with Limited-Stage Small Cell Lung Cancer (NRG-LU005)
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October 28 2020
Follow Up Results on First Multicenter Trial to Report Outcomes of Salvage Low Dose Radiotherapy Brachytherapy after External Beam Radiotherapy for Prostate Cancer
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October 28 2020
NRG-RTOG 0617 Validates ERCC1/2 Genotypic Signature as a Radiosensitivity Biomarker for Tumor and Normal Tissues in Non-Small Cell Lung Cancer Patients
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October 28 2020
NRG Oncology Study on Treatment for Advanced Endometrial Cancer Chosen as ‘Editor’s Choice’ in Journal of Clinical Oncology
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October 27 2020
Updated Analysis of NRG-RTOG 9813 Indicates IDH1/2 Mutation Status is Statistically Associated with Better Overall and Progression-free Survival for Patients with Anaplastic Astrocytoma
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October 26 2020
Metastasis-Free Survival is a Strong Surrogate Endpoint for Overall Survival over Biochemical Failure for Men Receiving Salvage Radiotherapy for Recurrent Prostate Cancer
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October 26 2020
PILOT Grant Announcement for NRG NCORP Health Disparities Research
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October 26 2020
PILOT Grant Announcement for NRG NCORP Cancer Care Delivery Research
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October 26 2020
PILOT Grant Announcement for NRG NCORP Cancer Prevention and Control
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October 25 2020
Updated Results of NRG Oncology Trial Display Effectiveness of Gemcitabine and Daily Radiation for Bladder Preservation in Muscle-Invasive Bladder Cancer Patients
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October 24 2020
NRG-BN001 Photon IMRT Treatment Group Displays No Significant Survival Difference Between Arms for Patients with Glioblastoma, Proton Treatment Group Still Accruing
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October 12 2020
Exploring the Addition of Nivolumab to Platinum-Gemcitabine for Recurrent or Metastatic Nasopharyngeal Cancer (NRG-HN007)
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October 12 2020
Breast Cancer Awareness Month: Why it Matters
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September 29 2020
NCI Proton Letter for NRG Sites to Send to Patients' Insurance Carrier
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September 14 2020
NRG Oncology Health Disparities Committee (HDC) Update (9/14/2020)
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September 14 2020
Can Immunotherapy Improve Outcomes for Patients with MGMT Unmethylated Glioblastoma on NRG-BN007?
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September 14 2020
The Raptor Trial (NRG-LU007) for Extensive Stage Small Cell Lung Cancer
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September 14 2020
A New Trial in Localized High Risk Prostate Cancer (GU009) is Opening Soon!
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September 14 2020
Randomized phase III trial of radiation therapy with or without pembrolizumab for women with high intermediate risk mismatch repair deficient (dMMR) endometrioid endometrial cancer (NRG-GY020)
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August 28 2020
Genomic Analysis Predicts Survival Benefit of Adjuvant Chemotherapy Following Radiotherapy over Radiotherapy Alone in Low-Grade Gliomas in NRG Oncology Clinical Trial
Genomic Analysis Predicts Survival Benefit of Adjuvant Chemotherapy Following Radiotherapy over Radiotherapy Alone in Low-Grade Gliomas in NRG Oncology Clinical Trial Read more
August 20 2020
Calling all NRG Oncology Investigators! NRG-GY022 is open for ANY cancer patient undergoing carboplatin treatment, any cycle!
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August 07 2020
Dr. Bauman named Co-Chair of the NCI Cancer Prevention Steering Committee
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August 07 2020
NRG Oncology Trial Compares Sentinel Lymph Node Biopsy to Standard Neck Dissection for patients with Early-stage Oral Cavity Cancer
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August 07 2020
The NRG Oncology SOROCk Trial Compares Two Surgical Procedures in Women with BRCA1 Mutations to Assess Risk Reduction for Ovarian Cancer
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July 29 2020
André Robidoux, MD, long-time researcher with the NSABP and NRG Oncology, dies in Montreal
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July 17 2020
NRG General Session at NRG 2020
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July 17 2020
NRG NCORP Town Hall at NRG 2020
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July 17 2020
NRG Town Hall with the NCI Director at NRG 2020
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July 16 2020
The NRG Oncology Digital Health Symposium at NRG 2020
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July 16 2020
The NRG Oncology FORTE Protocol Workshop at NRG 2020
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July 16 2020
The NRG Oncology Protocol Support Committee’s Clinical Trials and Clinical Research Associate Workshops at NRG 2020
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June 29 2020
NRG Oncology Biospecimen Bank Awarded NCI Funding for Next 6 Years with ‘Exceptional’ Score
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June 24 2020
Joan B. Goldberg, MPH, approaches retirement from NRG Oncology and the NSABP Foundation
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May 29 2020
Trastuzumab Combined with Trimodality Treatment Does Not Improve Outcomes for Patients with HER2-Overexpressing Esophageal Cancer on NRG Oncology Trial
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May 29 2020
MTX-based Chemotherapy Combined with Low-Dose, Whole-Brain Radiotherapy Improves Progression-free Survival for Patients with Newly Diagnosed CNS Lymphoma
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May 29 2020
Combined Cediranib and Olaparib Presents Similar Activity to Standard of Care Treatment for Platinum-Sensitive Ovarian Cancer
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May 29 2020
Trastuzumab Achieves Slight Reduction in Recurrence for Women with HER2-Positive Ductal Carcinoma in Situ on NRG Oncology Trial NSABP B-43
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May 21 2020
Project Team Member Application – Ipatasertib
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May 13 2020
An Overview of Burnout Syndrome
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May 13 2020
NRG Oncology Celebrates Nurses during the International Year of the Nurse and National Nurses Month
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May 13 2020
Having a Say: The EndBrainCancer Initiative wants patient concerns reflected in national treatment guidelines
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May 13 2020
Does Radiotherapy Improve Outcomes for Patients with Resected WHO Grade II Meningioma? (NRG-BN003)
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May 13 2020
NRG Oncology COVID-19 Update for 5/13/2020
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April 15 2020
NRG Oncology Trial Explores the Addition of Novel Hormonal Therapy Agents to the Usual Treatment for Node-Positive Prostate Cancer
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April 15 2020
NRG Oncology Appoints New Patient Advocate Committee Chair, Dorothy Erlanger
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April 15 2020
Patient Advocate Perspective: The Importance of Awareness
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April 15 2020
Sentinel Lymph Node Biopsy in Early Stage Oral Cavity Disease (NRG-HN006)
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April 15 2020
Treatment De-intensification for Early-Stage HPV-Positive Oropharyngeal Cancer (NRG-HN005)
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April 15 2020
Concurrent Chemoradiation in Cisplatin-Ineligible Locoregionally Advanced Head and Neck Cancer (NRG-HN004)
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April 13 2020
NRG Oncology Leadership Special Message Regarding COVID-19
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March 30 2020
NRG Oncology Appoints New Patient Advocate Committee Chair, Dorothy Erlanger
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March 23 2020
NRG Oncology Leadership Special Message Regarding COVID-19 - March 23, 2020
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March 19 2020
NCI Requests Letters of Intent for Laboratories to Participate in the NCI-ComboMATCH Clinical Trial
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March 14 2020
Special Message from NRG Oncology Leadership
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March 10 2020
Intensity Modulated Radiotherapy Improved Patient-Reported Outcomes on NRG Oncology Clinical Trial
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March 10 2020
NCTN Disease Diagrams – A Helpful Tool
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March 10 2020
Total Neoadjuvant Therapy in the Treatment of Locally Advanced Rectal Cancer
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March 10 2020
The Impact of ctDNA on the Treatment of Colon Cancer: The COBRA Trial
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March 09 2020
NRG Oncology is Seeking Applications for Travel Awards to the Next NRG Meeting in July 2020
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March 09 2020
The Revised 2020 BIQSFP Guidelines are Available
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March 09 2020
US COVID-19 Update
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February 17 2020
A Memorial for Dr. Janet Wolter-Grip
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February 17 2020
NRG Oncology Protocol Development Retreat
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February 17 2020
NRG-LU006: Testing the Addition of Targeted Radiation Therapy to Surgery and the Usual Chemotherapy Treatment for Stage I-IIIA Malignant Pleural Mesothelioma
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February 17 2020
NRG-CC008 Trial to Open
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February 17 2020
National Cancer Prevention Month
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February 17 2020
NRG Oncology Weekly Broadcast - February 17, 2020
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February 17 2020
NRG Oncology Trial Shows Hippocampal Avoidance During Whole-Brain Radiotherapy for Brain Metastases Reduces Risks of Cognitive Toxicity and Neurologic Symptoms
Results from the NRG Oncology clinical study NRG-CC001 concluded that lowering radiotherapy dose to hippocampal stem cells improves cognitive and patient-reported outcomes for patients with brain metastases. Read more
February 14 2020
EXTENDED DEADLINE NRG Oncology NCORP solicits PILOT projects addressing NRG NCORP Cancer Care Delivery Research (CCDR) priorities
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February 14 2020
EXTENDED DEADLINE: NRG Oncology NCORP is soliciting PILOT projects for applications focused on NRG NCORP Cancer Prevention and Control (CPC) priorities
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January 22 2020
NRG-LU004 – Cohort 1 has Completed Accrual
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January 22 2020
Protocol Support Committee Column: Safe Handling of Hazardous Drugs
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January 22 2020
Cervical Cancer Awareness Month Highlight: NRG-GY017
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January 22 2020
Cervical Cancer Awareness Month Highlight: NRG-GOG-9929
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January 22 2020
NRG Oncology Semiannual Meeting Recap: Social Media Workshop and Twitter 1-on-1
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January 22 2020
NRG Oncology Semiannual Meeting Recap: Plenary Session
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December 16 2019
NRG Oncology Trial shows that standard of care chemoradiation for Stage III non-small cell lung cancer is superior to two tested alternatives
Lung cancer is the leading cause of cancer death in the United States and approximately 75-80% of all cases are non-small cell lung cancer (NSCLC). Of these, 30-40% are considered locally advanced and are categorized as either Stage IIIA or IIIB. Read more
December 13 2019
Breast-conserving treatment without surgery not supported at this time: Results of NRG Oncology study BR005
Results from NRG Oncology's BR005 study show that breast-conserving treatment without surgery cannot be recommended, based on the study criteria of clinical complete response, radiological complete response (rCR)/near rCR, and negative tumor bed biopsies. Read more
December 12 2019
Extended letrozole therapy improves disease-free survival (DFS) in postmenopausal women with HR+ breast cancer: 10-year results of NRG Oncology/NSABP B-42 trial
In the updated results from NRG Oncology/NSABP B-42 trial through 10 years of observation, extending letrozole therapy for additional five years after five years of adjuvant endocrine therapy resulted in a statistically significant improvement in the 10-year disease-free survival (DFS) of postmenopausal women with hormone-receptor-positive breast cancer. Read more
November 27 2019
NRG Oncology trial shows immunotherapy is safe following chemoradiotherapy for women with node-positive cervical cancer
Results from the NRG Oncology phase I clinical trial NRG-GOG 9929 show that utilizing the immunotherapy drug ipilimumab after chemoradiotherapy (CRT) is tolerated in the curative treatment of women with lymph node-positive cervical cancer. The maximum tolerated dose of ipilimumab was determined to be 10 mg/kg. Read more
October 10 2019
NRG Oncology Currents October 2019 eNewsletter
NRG Oncology Currents - NRG Oncology's monthly eNewsletter edition for October 2019. Read more
September 29 2019
Trametinib Improves Outcomes for Women with Low-Grade Serous Carcinoma of the Ovary/Peritoneum on NRG Oncology Trial
NRG Oncology and the National Cancer Research Network (NCRN) collaborated on a phase II/III clinical trial NRG-GOG 0281 which compared treatment using the MEK inhibitor trametinib to the physician’s choice of standard of care treatment for women with low-grade serous ovary or peritoneal cancer (LGSOC). Results of this trial indicate that trametinib was able to improve progression-free survival (PFS) and objective response rate (ORR). Improvements in response duration and overall survival (OS) were also observed. These results were presented at the 2019 European Society for Medical Oncology Congress in September 2019. Read more
September 19 2019
Protocol Support Committee – Call for Applications
Do you want to become more involved in NRG Oncology?There is an opportunity to work with your colleagues on the Protocol Support Committee (PSC) Clinical Trial Nurse Committee (CTN), the Clinical Research Associate (CRA) Committee and/or to serve on one of the PSC Working Groups: Education and Training, Mentorship, Protocol Review or Quality Control. Read more
September 19 2019
A Letter from the NRG Oncology Group Chairs on Rare Tumor Trials
We were recently asked to provide a letter to support an NRG Oncology investigator’s response to a query at their institution related to a study not meeting the accrual threshold for remaining open. You likely have some experience with being questioned about maintaining an open study that doesn’t appear to be accruing due to the rare-tumor type involved. We agreed to pull together a letter to provide support, and thought to share this more broadly. Read more
September 16 2019
Reduced-Dose Intensity-Modulated Radiotherapy with Cisplatin Meets Predetermined Benchmarks for Progression-Free Survival and Swallowing-Related Quality of Life for Oropharyngeal Cancer
Results of the NRG Oncology clinical trial NRG-HN002 indicated that the combination of intensity-modulated radiotherapy (IMRT) and cisplatin was able to meet acceptability criteria for progression-free survival (PFS) and swallowing-related quality of life for patients who have p16-positive, non-smoking-associated oropharyngeal cancer. These results were highlighted during the plenary session at the American Society for Radiation Oncology’s (ASTRO) Annual Meeting in September 2019 and this presentation was the recipient of ASTRO and ABR Foundation’s Steven A. Leibel Memorial Award at the Meeting. The abstract was one of four abstracts chosen from over 3,000 submitted abstracts for the plenary session. Read more
September 16 2019
NRG Oncology Substudy Show Cosmetic Changes are Equivalent after Whole Breast Irradiation versus Partial Breast Irradiation for Women with Early Stage Breast Cancer
Results from the Quality of Life substudy of the NRG Oncology clinical trial NSABP B-39/RTOG 0413 indicate that women rated post-lumpectomy partial breast irradiation (PBI) as equivalent to whole breast irradiation (WBI) in terms of cosmetic outcomes and satisfaction from baseline to three years following radiotherapy treatment. Treating physicians from the accruing site rated PBI as inferior to WBI while physicians who performed central review of digital photos blinded to treatment arm and time-point rated cosmetic outcome from PBI equivalent to WBI. These results were presented at the annual meeting of the American Society for Radiation Oncology (ASTRO) during the Plenary Session. The abstract was one of four abstracts chosen from over 3,000 submitted abstracts for the plenary session. Read more
September 16 2019
NRG Oncology Trial Shows no Difference in Pain Response between Stereotactic Body Radiotherapy and Conventional Radiotherapy for Patients with Spinal Metastases
A Phase III, NRG Oncology clinical trial that compared radiosurgery (SRS) or stereotactic body radiotherapy (SBRT) to the conventional radiotherapy (cEBRT) for patients with spinal metastases indicated that there was no statistically significant difference between the treatments for pain response, adverse events, FACT-G, BPI, and EQ-5D scores. These results were presented during the plenary session of the American Society of Radiation Oncology’s (ASTRO) Annual Meeting in September 2019. The abstract was one of four abstracts chosen from over 3,000 submitted abstracts for the plenary session. Read more
September 16 2019
Pre-Salvage RT PSA is Predictive of Hormone Therapy Benefit with Salvage RT for Men with Recurrent Prostate Cancer on NRG Oncology Trial
Initial results of NRG Oncology Clinical Trial RTOG 9601 in men with biochemically recurrent prostate cancer receiving salvage radiotherapy (SRT) demonstrated improvement in OS from the addition of long-term hormone therapy to SRT. However, a secondary analysis indicates that all patients do not benefit and the addition of long-term anti-androgen therapy did not improve overall survival (OS) rates and could increase other-cause mortality (OCM) for some patients depending on pre-treatment PSA level. Read more
September 12 2019
NRG Oncology Highlighted at ASTRO 2019, with all 4 ASTRO Plenary Session Talks Featuring NRG Oncology Research
Results from twenty-one NRG Oncology clinical trials will be presented at the 2019 American Society for Radiation Oncology (ASTRO) Annual Meeting in Chicago, Illinois this September. All four ASTRO Plenary Session presentations are featuring NRG Oncology research, and these four highly impactful projects were chosen from over 3,000 submitted abstracts. The NRG Oncology presentations at the meeting will include results from trials for patients with brain tumors, spine metastases, or anal, breast, cervix, genitourinary, gynecologic, head and neck, liver, lung, or prostate cancer. Read more
August 14 2019
NRG-GY018: Kit Ordering
Please be advised that there is approximately a 10-day turnaround time to receive a kit from the day a kit is requested. There is no ability to expedite a kit shipment. Please consent your patients accordingly. Read more
August 12 2019
Weekly Broadcast
NSABP B-55, NRG-BN001, NRG-GI004, NRG-GY005, NRG-GY009, NRG-GY018 Read more
August 08 2019
NRG-CC007CD: Re-opened to Practice
NRG-CC007CD is now re-open to practice randomization. Read more
August 05 2019
Weekly Broadcast
RTOG 1112, NRG-GU006, NRG-GY014, NRG-GY005, NRG-GY009, NRG-LU005 Read more
July 29 2019
Special Edition - July 2019 NRG Meeting
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July 26 2019
NRG-GY014
Suspended to endometrial patients, ovarian suspension imminent Read more
July 24 2019
NRG Oncology is seeking an experienced Patient Advocate to serve as Chair for its Patient Advocate Committee
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July 01 2019
Independence Day Holiday Closures for Operations, SDMCs, Biospecimen Banks, Serum Bank, and McKesson Clinical Research Services.
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June 03 2019
Patients who Received Partial Breast Irradiation without Chemotherapy Experienced Less Fatigue, Slightly Poorer Cosmesis on NRG Oncology Trial
Patient-reported outcome (PRO) data indicates that partial breast irradiation (PBI) is more convenient than whole breast irradiation (WBI) for women with breast cancer who do not receive adjuvant chemotherapy. These participants on the NRG Oncology clinical trial NSABP B-39/RTOG 0413 also experienced less post-treatment fatigue and slightly poorer cosmesis at 36 months following treatment, whereas cosmesis was equivalent at 36 months in women who received chemotherapy and PBI or WBI. These outcomes were presented at the American Society of Clinical Oncology (ASCO) Annual Meeting and the abstract was designated as a “Best of ASCO” abstract. Read more
June 03 2019
NRG Oncology Trial Sets New Standard Regimen for Women with Uterine Carcinosarcomas
Results from the phase III NRG Oncology clinical trial GOG 0261 comparing paclitaxel plus carboplatin (PC) to paclitaxel plus ifosfamide (PI) in women with stage I-IV, recurrent carcinosarcoma of the uterus or ovary, indicate that the PC combination treatment should be considered a standard of care for this patient population. The study concludes that among uterine cancer patients treatment with PC was not inferior to PI based on the primary objective overall survival (OS), and PC was associated with longer progression-free survival (PFS) outcomes when compared with PI. These results were recently presented at the American Society for Clinical Oncology (ASCO) Annual Meeting and was awarded a “Best of ASCO” designation. Read more
June 03 2019
Analyses of NRG Oncology/RTOG 9802 Suggests Both IDH-mutant WHO-defined Molecular Subgroups of High-risk Low-Grade Gliomas May Benefit from the Addition of PCV Chemotherapy to Radiotherapy
A recent, updated predictive analysis of the three WHO-defined molecular subgroups based on isocitrate dehydrogenase 1/2 (IDH) mutation status and 1p/19q co-deletion status represented in the high-risk treatment arms of the NRG Oncology clinical trial NRG-RTOG 9802 indicates that both IDH-mutant sub-groups (IDHmut-noncodel and IDHmut-codel) could benefit from the addition of PCV chemotherapy to radiotherapy treatment. This data was presented during a “Best of ASCO” oral presentation in the Central Nervous Systems Tumors Session at the American Society of Clinical Oncology (ASCO) Annual Meeting. Read more
June 01 2019
Initial Experimental Treatment Arm Results from NRG Oncology Trial Suggests Total Neoadjuvant Therapy for Locally Advanced Rectal Cancer is Safe
Results from the first experimental arm using veliparib as part of total neoadjuvant therapy (induction chemotherapy followed by chemoradiotherapy and surgery; TNT) in patients with locally advanced rectal adenocarcinoma on the NRG Oncology Phase II clinical trial NRG-GI002 were recently presented at the American Society of Clinical Oncology (ASCO) Annual Meeting. Results were reported on the primary endpoint of pathological regression via the neoadjuvant rectal cancer (NAR) score, a short-term clinical trial surrogate endpoint. Read more
June 01 2019
NRG Oncology Trial Shows Tolerability of Metformin for Non-Small Cell Lung Cancer, No Improvement in Survival Outcomes between Treatments
Initial results of NRG-LU001 indicate that, although the diabetes agent metformin was well-tolerated by patients, the agent has not clearly improved progression-free survival (PFS) or overall survival (OS) for trial participants with locally advanced non-small cell lung cancer (NSCLC). These results are based on local center reported outcomes. Trial participants will continue to be followed for changes in their status. The initial report of these results were presented at the American Society of Clinical Oncology (ASCO) Annual Meeting and the abstract was awarded a “Best of ASCO” designation. Read more
May 20 2019
Memorial Day closures for Operations, SDMCs, Biospecimen Banks, Serum Bank, and McKesson Clinical Research Services.
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May 03 2019
Patient Reported Outcomes: Upping the game for PRO methods and design in clinical trials
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April 23 2019
Project Team Member Application – Abemaciclib
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April 17 2019
NRG Oncology SDMC Awarded NCI Funding for Next 6 Years with ‘Outstanding’ Score
The NRG Oncology Statistics and Data Management Center (SDMC) was notified that the center will be awarded six more years of funding from the National Cancer Institute (NCI) and will continue to serve the NCI National Clinical Trials Network (NCTN) group NRG Oncology. The total amount of funding requested for the six year effort was $68.9 million. During the peer review grant renewal process, the NRG Oncology SDMC was ranked within the “Outstanding” range with a score of 18. Read more
April 16 2019
NRG Oncology Awarded NCI Funding for Next 6 Years, Receives "Exceptional" Score
NRG Oncology, a National Cancer Institute (NCI) National Clinical Trials Network (NCTN) group conducting practice-changing clinical and translational research, has been awarded funding of $16.5 Million by the NCI for the next six years to continue its work as a lead protocol organization (LPO) program. During the peer review grant renewal process, NRG Oncology received the “exceptional” score of 16. Read more
March 18 2019
Prophylactic Cranial Irradiation Improves Disease-Free Survival and Brain Metastasis Rates for Locally Advanced Non-Small Cell Lung Cancer
Prophylactic cranial irradiation (PCI), a technique used to prevent the clinical development of brain metastases, is established as a standard approach for many patients with small cell lung cancer (SCLC) after initial therapy. While studies established that PCI decreases the incidence of brain metastases for patients with locally advanced non-small cell lung cancer (LA-NSCLC), there is no established indication for its use for such NSCLC patients. Read more
March 12 2019
NRG Oncology Trial Suggests Adding Docetaxel-based Chemotherapy to Standard Treatment Should be Considered for Men with High-Risk Prostate Cancer
According to the American Cancer Society, prostate cancer is the second most common cause of cancer-related death among men in the United States in 2018. Currently, the standard of care treatment for high-risk, localized prostate cancer is a combination of radiotherapy (RT) and long-term (24-36 month) androgen suppression (AS). Researchers theorized that adding adjuvant docetaxel, a cytotoxic chemotherapy drug, to the standard of care RT and long-term AS treatment could potentially improve overall survival and clinical outcomes for men with localized, high-risk prostate cancer. Read more
March 05 2019
Project Team Member Application – BAY 1895344
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February 21 2019
NRG Oncology NCORP Pilot Projects
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February 15 2019
NRG Oncology Trial Affirms Hypofractionated Radiotherapy Should Be Considered New Practice Standard for Men with Low Risk Prostate Cancer
Results from the NRG Oncology clinical study NRG-RTOG 0415 determined that a hypofractionated radiotherapy schedule (H-RT), a treatment schedule that delivers a total dose of radiotherapy over a shorter period of time, is not worse than the conventional radiotherapy schedule (C-RT) in terms of bowel, bladder, sexual, and general quality of life (QOL) as well as anxiety and depression for men with low risk prostate cancer. Read more
December 20 2018
Time to Biochemical Failure Could be Used as a Surrogate Endpoint in Treatment of Locally Advanced Prostate Cancer
An analysis of the NRG Oncology clinical trial NRG-RTOG 9202 showed that the interval of time to biochemical failure (IBF), or the time it takes for previously treated cancer to return as indicated by prostate specific antigen (PSA) rise, could be used as a surrogate endpoint for locally advanced prostate cancer. Read more
December 18 2018
December 18, 2018 - Join the Head and Neck Cancer Alliance in Celebrating the 2019 Oral, Head and Neck Cancer Awareness Week®, April 7-14
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December 17 2018
December 17, 2018
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December 17 2018
December 17, 2018 - Project Team Member Application – Hu5F9-G4
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December 13 2018
December 13, 2018 - NCTN and NCORP CIRB Requirement Policy: Implementation Date Effective March 1, 2019
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December 06 2018
Accelerated Partial Breast Irradiation, Although Close, was Not Equivalent to Whole Breast Irradiation To Control Ipsilateral Breast Tumor Recurrence
Data from the NRG (NSABP B-39/RTOG 0413) trial indicated that ipsilateral breast tumor recurrence (IBTR) rates 10 years after treatment could not reject the hypothesis that accelerated partial breast irradiation (PBI) after lumpectomy was inferior to whole breast irradiation (WBI), according to a presentation at the 2018 San Antonio Breast Cancer Symposium, held Dec. 4–8. Read more
November 29 2018
Tocagen and NRG Oncology to Collaborate on a Phase 2/3 Trial of Toca 511 & Toca FC in Newly Diagnosed Glioblastoma
Tocagen Inc. (Nasdaq: TOCA), a late clinical-stage, cancer-selective gene therapy company and NRG Oncology, a member of the National Cancer Institute’s (NCI) National Clinical Trial Network (NCTN), today announced that the NCI Cancer Therapy and Evaluation Program (CTEP) Brain Malignancies Steering Committee has approved a concept to develop a clinical trial utilizing the investigational therapeutic regimen Toca 511 (vocimagene amiretrorepvec) & Toca FC (flucytosine, extended-release) for the treatment of patients with newly diagnosed glioblastoma (GBM). Read more
November 12 2018
November 12, 2018
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November 05 2018
November 5, 2018
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September 13 2018
September 13, 2018 Project Team Member Application – DS-8201a
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August 27 2018
August 27, 2018
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August 23 2018
August 23, 2018
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July 19 2018
July 19, 2018
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June 25 2018
June 25, 2018
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June 25 2018
June 25, 2018
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June 18 2018
June 18, 2018 - An Important Word from Quality Assurance About Protocol Amendments
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May 21 2018
May 21, 2018
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May 07 2018
May 7, 2018 - Project Team Member Application – Rogaratinib
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April 04 2018
April 4, 2018 Dr. Chakravarti Selected to Serve on NCI Advisory Board of Scientific Counselors
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March 30 2018
March 30, 2018 Dr. Felix Feng Selected as the New NRG Oncology Genitourinary Cancer Committee Chair
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March 23 2018
March 23, 2018
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March 12 2018
March 12, 2018 - Project Team Member Application – Radium-223
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March 07 2018
March 7, 2018
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February 19 2018
February 19, 2018 - NRG Oncology NCORP Pilot Projects
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February 14 2018
February 14, 2018 - NRG Oncology Appoints NCORP Investigator, Matthew Hudson, as Cancer Care Delivery Research Committee Co-Chair
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February 13 2018
February 13, 2018 - Aghajanian Appointed as NRG Oncology Gynecologic Cancer Committee Chair
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February 01 2018
February 1, 2018 - NRG Oncology Appoints Kati Stoermer for New Executive Director Role
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