| NRG-LU008 | Phase III Prospective Randomized Trial of Primary Lung Tumor Stereotactic Body Radiation Therapy Followed by Concurrent Mediastinal Chemoradiation for Locally Advanced Non-Small Cell Lung Cancer | Open to Accrual | III | >Lung [LU] | Small Cell |
| NRG-BR008 | NRG-BR008: A Phase III Randomized Trial of Radiotherapy Optimization for Low-Risk HER2-Positive Breast Cancer (HERO) | Open to Accrual | III | >Breast [BR] | Breast |
| EAY191-N2 | EAY191-N2: Phase 2 Trial of Fulvestrant and Binimetinib in Patients With Hormone Receptor-Positive Metastatic Breast Cancer With a Frameshift or Nonsense Mutation or Genomic Deletion in NF1
| Open to Accrual | II | >Breast [BR] | Breast |
| EAY191-N4 | Molecular Analysis for Combination Therapy Choice (ComboMATCH) EAY191-N4: A Randomized Trial of Selumetinib and Olaparib or Selumetinib Alone in Patients with Recurrent or Persistent RAS Pathway Mutant Ovarian and Endometrial Cancers - A ComboMATCH Treatment Trial
| Open to Accrual | II | >Gynecologic [GY] | Multiple |
| NRG-GY028 | A Phase IB and Randomized Phase II trial of Megestrol Acetate with or without Ipatasertib in Recurrent or Metastatic Endometrioid Endometrial Cancer
| Open to Accrual | I/II | >Gynecologic [GY] | Uterine Corpus |
| NRG-HN010 | A Controlled, Randomized Phase II Trial of Docetaxel Plus Trastuzumab Versus Ado-Trastuzumab Emtansine for Recurrent, Metastatic, or Treatment-Naïve, Unresectable Her2-Positive Salivary Gland Cancer | Open to Accrual | II | >Head and Neck [HN] | Head and Neck |
| NRG-CC010 | A Phase III Trial of the Impact of Sentinel Lymph Node Mapping On Patient Reported Lower Extremity Limb Dysfunction in Endometrial Cancer
| Open to Accrual | III | >Gynecologic [GY] | Uterine Corpus |
| NRG-BN012 | A Randomized Phase III Trial Of Pre-Operative Compared To Post-Operative Stereotactic Radiosurgery In Patients With Resectable Brain Metastases | Open to Accrual | III | >Brain [BN] | Brain Mets |
| NRG-GY026 | A Phase II/III Study Of Paclitaxel/Carboplatin Alone Or Combined With Either Trastuzumab And Hyaluronidase-Oysk (Herceptin Hylecta) Or Pertuzumab, Trastuzumab, And Hyaluronidase-Zzxf (Phesgo) In Her2 Positive, Stage I-Iv Endometrial Serous Carcinoma Or Carcinosarcoma
| Open to Accrual | II/III | >Gynecologic [GY] | Uterine Corpus |
| NRG-GY029 | A Randomized Phase II trial comparing the combination of PI3K inhibitor Copanlisib (BAY 80-6946) and PARP inhibitor Olaparib (AZD2281) to standard chemotherapy in patients with recurrent platinum resistant ovarian, fallopian tube, or primary peritoneal cancer who have progressed through prior PARP inhibitor therapy
| Closed to Accrual | II | >Gynecologic [GY] | Ovarian |
| NRG-GY027 | NRG-GY027: PHASE I/IB SAFETY AND PHARMACODYNAMIC STUDY OF NEOADJUVANT (NACT) PACLITAXEL AND CARBOPLATIN WITH IPATASERTIB AS INITIAL THERAPY OF OVARIAN CANCER PTMA 100805
| Temporarily Closed to Accrual | I | >Gynecologic [GY] | Ovarian |
| NRG-GU012 | Randomized Phase II Stereotactic Ablative Radiation Therapy (SABR) For Metastatic Unresected Renal Cell Carcinoma (RCC) Receiving Immunotherapy (Samurai) | Open to Accrual | II | >Genitourinary [GU] | Prostate |
| NRG-GI008 | Colon Adjuvant Chemotherapy based on Evaluation of Residual Disease (CIRCULATE-US) | Open to Accrual | II/III | >Gastrointestinal [GI] | Colorectal |
| NRG-GY025 | NRG-GY025: A RANDOMIZED PHASE II TRIAL OF NIVOLUMAB AND IPILIMUMAB COMPARED TO NIVOLUMAB MONOTHERAPY IN PATIENTS WITH DEFICIENT MISMATCH REPAIR SYSTEM RECURRENT ENDOMETRIAL CARCINOMA
| Open to Accrual | II | >Gynecologic [GY] | Uterine Corpus |
| NRG-GU011 | A Phase II Double-Blinded, Placebo Controlled Trial of Prostate Oligometastatic Radiotherapy with or without Androgen Deprivation Therapy in Oligometastatic Prostate Cancer (NRG Promethean) | Open to Accrual | II | >Genitourinary [GU] | Prostate |
| NRG-BN011 | A Phase III Trial of Lomustine-Temozolomide Combination Therapy Versus Standard Temozolomide in Patients with Methylated MGMT Promoter Glioblastoma | Open to Accrual | III | >Brain [BN] | Malignant Glioma |
| NRG-HN009 | Randomized Phase II/III Trial of Radiation with High-Dose Cisplatin (100 mg/m2) Every Three Weeks versus Radiation with Low-Dose Weekly Cisplatin (40 mg/m2) for Patients with Locoregionally Advanced Squamous Cell Carcinoma of The Head And Neck (SCCHN) | Open to Accrual | II/III | >Head and Neck [HN] | Head and Neck |
| NRG-CC005 | Five or Ten Year Colonoscopy for 1-2 Non-Advanced Adenomatous Polyps | Open to Accrual | III | >Prevention [CC] | Colorectal |
| NRG-GU010 | Parallel Phase III Randomized Trials Of Genomic-Risk Stratified Unfavorable Intermediate Risk Prostate Cancer: De-Intensification And Intensification Clinical Trial Evaluation (Guidance) | Open to Accrual | III | >Genitourinary [GU] | Prostate |
| NRG-GY024 | Groningen International Study on Sentinel Nodes in Vulvar Cancer (GROINSS-V) III: A Prospective Phase II Treatment Trial | Open to Accrual | II | >Gynecologic [GY] | Other |
| NRG-BN010 | A Safety Run-In and Phase II Study Evaluating the Efficacy, Safety, and Impact on the Tumor Microenvironment of the Combination of Tocilizumab, Atezolizumab, and Fractionated Stereotactic Radiotherapy in Recurrent Glioblastoma | Temporarily Closed to Accrual | I/II | >Brain [BN] | Other |
| NRG-BR007 | A Phase III Clinical Trial evaluating De-escalation of Breast Radiation for Conservative Treatment of Stage I, Hormone Sensitive, HER2-Negative, Oncotype Recurrence Score Less than or Equal to 18: The DEBRA Trial | Open to Accrual | III | >Breast [BR] | Breast |
| NRG-GY023 | A Randomized Phase II Trial of Triplet Therapy (A PD-L1 Inhibitor Durvalumab (MEDI4736) in Combination With Olaparib and Cediranib) Compared to Olaparib and Cediranib or Durvalumab (MEDI4736) and Cediranib or Standard of Care Chemotherapy in Women With Platinum-Resistant Recurrent Epithelial Ovarian Cancer, Primary Peritoneal or Fallopian Cancer Who Have Received Prior Bevacizumab | Closed to Accrual | II | >Gynecologic [GY] | Ovarian |
| GOG-0268 | A Phase II Evaluation of Temsirolimus (CCI-779) (NCI Supplied Agent: 683864, IND #61010) in Combination with Carboplatin and Paclitaxel followed by Temsirolimus Consolidation as First-line Therapy in the Treatment of Clear Cell Carcinoma of the Ovary. | Closed to Accrual | II | >Gynecologic [GY] | Ovarian |
| NRG-CC009 | Phase III Trial of Stereotactic Radiosurgery (SRS) versus Hippocampal-Avoidant Whole Brain Radiotherapy (HA-WBRT) for 10 or Fewer Brain Metastases from Small Cell Lung Cancer | Open to Accrual | III | >Symptom Management [CC] | Other |
| GOG-0214 | Phase II Double Blind Randomized Trial Evaluating the Biologic Effect of Levonorgestrel on the Ovarian Epithelium in Women at High Risk for Ovarian Cancer (IND# 79,610)
| Terminated | II | >Gynecologic [GY] | Ovarian |
| GOG-0207 | A Randomized Double-Blind Phase II Trial of Celecoxib, A COX-2 Inhibitor, In The Treatment of Patients With Cervical Intraepithelial Neoplasia 2/3 or 3 | Terminated | II | >Gynecologic [GY] | Cervix |
| GOG-0199 | Prospective Study of Risk-Reducing Salpingo-Oophorectomy and Longitudinal CA-125 Screening Among Women at Increased Genetic Risk of Ovarian Cancer
| Terminated | I | >Gynecologic [GY] | Ovarian |
| NRG-BN009 | Phase III Trial of Salvage Stereotactic Radiosurgery (SRS) or SRS + Hippocampal-Avoidant Whole Brain Radiotherapy (HA-WBRT) for First or Second Distant Brain Relapse After Upfront SRS With Brain Metastasis Velocity ≥4 Brain Metastases/Year
| Open to Accrual | III | >Brain [BN] | Other |
| NRG-HN008 | Phase I Trial With Expansion Cohort of DNA-PK Inhibition and IMRT In Cisplatin-Ineligible Patients with Stage 3-4 Local-Regionally Advanced Head and Neck Squamous Cell Carcinoma (HNSCC) | Open to Accrual | I | >Head and Neck [HN] | Head and Neck |
| NRG-GU009 | Parallel Phase III Randomized Trials For High Risk Prostate Cancer Evaluating De-Intensification For Lower Genomic Risk and Intensification of Concurrent Therapy for Higher Genomic Risk with Radiation (Predict-RT*) *Prostate RNA Expression/Decipher To Individualize Concurrent Therapy with Radiation | Open to Accrual | III | >Genitourinary [GU] | Prostate |
| NRG-HN007 | An Open Label, Phase III Study of Platinum-Gemcitabine With or Without Nivolumab in the First-Line Treatment of Recurrent or Metastatic Nasopharyngeal Carcinoma | Closed to Accrual | III | >Head and Neck [HN] | Head and Neck |
| EA8185 | ECOG-ACRIN/NRG Joint Study:A Study of Chemotherapy and Radiation Therapy Compared to Chemotherapy and Radiation Therapy Plus MEDI4736 (Durvalumab) Immunotherapy for Bladder Cancer Which Has Spread to the Lymph Nodes, the INSPIRE Study | Open to Accrual | II | >Genitourinary [GU] | Bladder |
| NRG-LU007 | RAndomized Phase II/III Trial of Consolidation Radiation + Immunotherapy for ES-SCLC: RAPTOR Trial | Open to Accrual | II/III | >Lung [LU] | Small Cell |
| GOG-0210 | A Molecular Staging Study of Endometrial Carcinoma | Terminated | I | >Gynecologic [GY] | Uterine Corpus |
| NRG-BN007 | A Randomized Phase II/III Open-Label Study of Ipilimumab and Nivolumab Versus Temozolomide In Patients With Newly Diagnosed MGMT (Tumor O-6-Methylguanine DNA Methyltransferase) Unmethylated Glioblastoma | Closed to Accrual | II/III | >Brain [BN] | Malignant Glioma |
| NRG-CC008 | A Non-Randomized Prospective Clinical Trial Comparing the Non-Inferiority of Salpingectomy to Salpingo-Oophorectomy to Reduce the Risk of Ovarian Cancer Among BRCA1 Carriers [SOROCk] | Open to Accrual | Other | >Prevention [CC] | Ovarian |
| NRG-HN006 | Randomized Phase II/III Trial Of Sentinel Lymph Node Biopsy Versus Elective Neck Dissection For Early-Stage Oral Cavity Cancer | Open to Accrual | II/III | >Head and Neck [HN] | Head and Neck |
| NRG-GI007 | Phase I Trial with Expansion Cohort of OBP-301 (Telomelysin) and Definitive Chemoradiation for Patients with Locally Advanced Esophageal And Gastroesophageal Adenocarcinoma Who are Not Candidates for Surgery | Temporarily Closed to Accrual | I | >Gastrointestinal [GI] | Esophageal |
| S1914 | SWOG/NRG Joint Study: A Randomized Phase III Trial of Induction/ Consolidation Atezolizumab (NSC #783608) + SBRT Versus SBRT Alone in High Risk, Early Stage NSCLC | Open to Accrual | III | >Lung [LU] | Other |
| S1806 | SWOG/NRG Joint Study: Phase III Randomized Trial of Concurrent Chemoradiotherapy with or without Atezolizumab in Localized Muscle Invasive Bladder Cancer | Open to Accrual | III | >Genitourinary [GU] | Bladder |
| NRG-GU008 | Randomized Phase III Trial Incorporating Apalutamide and Advanced Imaging into Salvage Treatment for Patients with Node-Positive Prostate Cancer After Radical Prostatectomy (INNOVATE*) *INtensifying treatment for NOde positive prostate cancer by VArying the hormonal ThErapy | Open to Accrual | III | >Genitourinary [GU] | Prostate |
| NRG-GY020 | A Phase III Randomized Trial of Radiation +/- Pembrolizumab (MK-3475) for Newly Diagnosed, Early Stage High Intermediate Risk Mismatch Repair Deficient (dMMR) Endometrioid Endometrial Cancer | Closed to Accrual | III | >Gynecologic [GY] | Uterine Corpus |
| NRG-LU006 | Phase III Randomized Trial of Pleurectomy/Decortication Plus Chemotherapy With or Without Adjuvant Hemithoracic Intensity-Modulated Pleural Radiation Therapy (IMPRINT) For Malignant Pleural Mesothelioma (MPM) | Open to Accrual | III | >Lung [LU] | Mesothelioma |
| NRG-GI005 | Phase II/III Study of Circulating tumOr DNA as a Predictive BiomaRker in Adjuvant Chemotherapy in Patients with Stage IIA
Colon Cancer (COBRA)
| Open to Accrual | II/III | >Gastrointestinal [GI] | Colorectal |
| NRG-GY021 | A Phase II Randomized Trial of Olaparib versus Olaparib plus Tremelimumab in Platinum-Sensitive Recurrent Ovarian Cancer | Closed to Accrual | II | >Gynecologic [GY] | Ovarian |
| NRG-GY022 | Assessment of Carboplatin Clearance Predictors: A PK Study on NCI-sponsored Clinical Trials or Standard of Care Treatments Using Carboplatin | Open to Accrual | II | >Gynecologic [GY] | Other |
| NRG-GY019 | A Randomized Phase III, Two-Arm Trial of Paclitaxel/Carboplatin/Maintenance Letrozole Versus Letrozole Monotherapy in Patients with Stage II-IV, Primary Low-Grade Serous Carcinoma of the Ovary or Peritoneum | Open to Accrual | III | >Gynecologic [GY] | Ovarian |
| GOG-0274 RTOG 1174 | A Phase III trial of adjuvant chemotherapy following chemoradiation as primary treatment for locally advanced cervical cancer compared to chemoradiation alone: THE OUTBACK TRIAL | Closed to Accrual | III | >Gynecologic [GY] | Cervix |
| NRG-GY018 | A PHASE III RANDOMIZED, PLACEBO-CONTROLLED STUDY OF PEMBROLIZUMAB (MK-3475, NSC #776864) IN ADDITION TO PACLITAXEL AND CARBOPLATIN FOR MEASURABLE STAGE III OR IVA, STAGE IVB OR RECURRENT ENDOMETRIAL CANCER | Closed to Accrual | III | >Gynecologic [GY] | Uterine Corpus |
| NRG-GY014 | A Phase II Study of Tazemetostat (EPZ-6438) (IND # 138671) in Recurrent or Persistent Endometrioid or Clear Cell Carcinoma of the Ovary, and Recurrent or Persistent Endometrioid Endometrial Adenocarcinoma | Closed to Accrual | II | >Gynecologic [GY] | Ovarian |
| NRG-GU006 | A Phase II, Double-Blinded, Placebo-Controlled Randomized Trial of Salvage Radiotherapy with or without Enhanced Anti-Androgen Therapy with Apalutamide in Recurrent Prostate Cancer | Closed to Accrual | II | >Genitourinary [GU] | Prostate |
| GOG-0237 | Comparative Analysis of CA-IX, p16, Proliferative Markers, and Human Papilloma Virus (HPV) in the Diagnosis of Significant Cervical Lesions in Patients with a Cytologic Diagnosis of Atypical Glandular Cells (AGC) | Closed to Accrual | I | >Gynecologic [GY] | Cervix |
| GOG-0238 | A Randomized Trial of Pelvic Irradiation with or without Concurrent Weekly Cisplatin in Patients with Pelvic-only Recurrence of Carcinoma of the Uterine Corpus | Closed to Accrual | II | >Gynecologic [GY] | Uterine Corpus |
| NRG-GY012 | A Randomized Phase II Study Comparing Single-Agent Olaparib, Single Agent Cediranib, and the Combinations of Cediranib/Olaparib, Olaparib/Durvalumab (MEDI4736), Cediranib/Durvalumab (MEDI4736), Olaparib/AZD5363 (Capivasertib) in Women with Recurrent, Persistent or Metastatic Endometrial Cancer.: A Platform Trial for Women with Recurrent or Persistent Endometrial Cancer | Open to Accrual | II | >Gynecologic [GY] | Uterine Corpus |
| NRG-GU007 | Randomized Phase II Trial of Niraparib With Standard Combination Radiotherapy and Androgen Deprivation Therapy (ADT) in High Risk Prostate Cancer (With Initial Phase I) | Open to Accrual | I/II | >Genitourinary [GU] | Prostate |
| RTOG-1112 | Randomized Phase III Study of Sorafenib versus Stereotactic Body Radiation Therapy followed by Sorafenib in Hepatocellular Carcinoma | Closed to Accrual | III | >Gastrointestinal [GI] | Liver |
| NRG-HN005 | A Randomized Phase II/III Trial of De-Intensified Radiation Therapy for Patients with Early-Stage, p16-Positive, Non-Smoking Associated Oropharyngeal Cancer | Open to Accrual | II/III | >Head and Neck [HN] | Head and Neck |
| NRG-LU003 | A Biomarker-Driven Protocol for Previously Treated ALK-Positive Non-Squamous NSCLC Patients: The NCI-NRG ALK Master Protocol | Closed to Accrual | II | >Lung [LU] | Other |
| NRG-CC004 | Phase II Double Blind Dose Finding Trial of Bupropion Versus Placebo For Sexual Desire in Women With Breast or Gynecologic Cancer | Terminated | II | >Symptom Management [CC] | Other |
| NRG-DT001 | A Phase Ib Trial of Neoadjuvant AMG-232 Concurrent with Preoperative Radiotherapy in Wild-Type P53 Soft Tissue Sarcoma (STS) | Closed to Accrual & Treatment | I | >Other [DT] | Sarcoma |
| RTOG-0924 | Androgen Deprivation Therapy and High Dose Radiotherapy With or Without Whole-Pelvic Radiotherapy in Unfavorable Intermediate or Favorable High Risk Prostate Cancer: A Phase III Randomized Trial | Closed to Accrual | III | >Genitourinary [GU] | Prostate |
| NRG-LU005 | Limited Stage Small Cell Lung Cancer (LS-SCLC): A Phase III Randomized Study of Chemoradiation Versus Chemoradiation Plus Atezolizumab | Open to Accrual | III | >Lung [LU] | Small Cell |
| NRG-LU002 | Maintenance Systemic Therapy Versus Local Consolidative Therapy (LCT) Plus Maintenance Systemic Therapy For Limited Metastatic Non-Small Cell Lung Cancer (NSCLC): A Randomized Phase II/III Trial | Temporarily Closed to Accrual | II/III | >Lung [LU] | Other |
| NRG-GY007 | A Phase I/II Study of Ruxolitinib with Front-Line Neoadjuvant and Post-Surgical Therapy in Patients with Advanced Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancer | Closed to Accrual | I/II | >Gynecologic [GY] | Ovarian |
| NRG-GU003 | A Randomized Phase III Trial Of Hypofractionated Post-Prostatectomy Radiation Therapy (HYPORT) Versus Conventional Post-Prostatectomy Radiation Therapy (COPORT) | Closed to Accrual | III | >Genitourinary [GU] | Prostate |
| NRG-BR005 | A Phase II Trial Assessing the Accuracy of Tumor Bed Biopsies in Predicting Pathologic Response in Patients with Clinical/Radiologic Complete Response after Neoadjuvant Chemotherapy in Order to Explore the Feasibility of Breast Conserving Treatment without Surgery | Temporarily Closed to Accrual | II | >Breast [BR] | Breast |
| NRG-CC003 | A Randomized Phase II/III Trial of Prophylactic Cranial Irradiation with or without Hippocampal Avoidance for Small Cell Lung Cancer | Closed to Accrual | II/III | >Symptom Management [CC] | Other |
| GOG-9923 | A Phase I Study of Carboplatin/Paclitaxel/CTEP-Supplied Bevacizumab(NSC #704865, IND #7921)and CTEP-Supplied Agent ABT-888(NSC #737664,IND# 77840)in Newly Diagnosed Patients with Previously Untreated Epithelial Ovarian, Fallopian Tube or Primary PeritCancer | Terminated | I | >Gynecologic [GY] | Ovarian |
| NSABP B-55 BIG 6-13 | OlympiA: A Randomised, Double-Blind, Parallel Group, Placebo-Controlled Multi-Centre Phase III Study to Assess the Efficacy and Safety of Olaparib Versus Placebo as Adjuvant Treatment in Patients with Germline BRCA1/2 Mutations and High Risk HER2 Negative Primary Breast Cancer Who Have Completed Definitive Local Treatment and Neoadjuvant or Adjuvant Chemotherapy | Closed to Accrual | III | >Breast [BR] | Breast |
| GOG-0277 | A phase III randomized trial of gemcitabine (nsc# 613327) plus docetaxel (nsc# 628503) followed by doxorubicin (nsc# 123127) versus observation for uterus-limited, high-grade uterine leiomyosarcoma | Terminated | III | >Gynecologic [GY] | Uterine Corpus |
| GOG-0260 | A Phase II Evaluation of Elesclomol Sodium and Weekly Paclitaxel in the Treatment of Recurrent or Persistent Platinum-Resistant Ovarian, Fallopian Tube or Primary Peritoneal Cancer (IND 110072) (NCT# 00888615). | Terminated | II | >Gynecologic [GY] | Ovarian |
| GOG-0186K | A Randomized Phase II Study of NCI Supplied Cabozantinib (NSC #761968 IND #116059) versus weekly paclitaxel (NSC #673089) in the Treatment of Persistent or Recurrent Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancer | Terminated | II | >Gynecologic [GY] | Ovarian |
| RTOG-0534 | A Phase III Trial of Short Term Androgen Deprivation With Pelvic Lymph Node or Prostate Bed Only Radiotherapy (SPPORT) in Prostate Cancer Patients With a Rising PSA After Radical Prostatectomy | Closed to Accrual | III | >Genitourinary [GU] | Prostate |
| RTOG-1119 | Phase II Randomized Study of Whole Brain Radiotherapy/Stereotactic Radiosurgery in Combination With Concurrent Lapatinib in Patients With Brain Metastasis From HER2-Positive Breast Cancer: A Collaborative Study of RTOG and KROG | Terminated | II | >Breast [BR] | Breast |
| NSABP B-31 | A Randomized Trial Comparing The Safety And Efficacy Of Adriamycin And Cyclophosphamide Followed By Taxol (AC?T) To That Of Adriamycin And Cyclophosphamide Followed By Taxol Plus Herceptin (AC?T + H) In Node-Positive Breast Cancer Patients Who Have Tumors That Overexpress HER2 | Terminated | III | >Breast [BR] | Breast |
| NRG-GY016 | A Phase II Study of MK-3475 (Pembrolizumab) (NSC #776864) + Epacadostat (NSC #766086) in Recurrent Clear Cell Carcinoma of the Ovary | Closed to Accrual | II | >Gynecologic [GY] | Ovarian |
| GOG-9926 | A Phase I Evaluation of Extended Field Radiation Therapy with Concomitant Cisplatin Chemotherapy Followed by Paclitaxel and Carboplatin Chemotherapy in Women with Cervical Carcinoma Metastatic to Para-Aortic Lymph Nodes | Terminated | I | >Gynecologic [GY] | Cervix |
| NRG-GY001 | A Phase II Trial of Cabozantinib (XL-184) (NSC #761968) in Women with Recurrent, Clear Cell Carcinoma of the Ovary, Fallopian Tube, or Peritoneum | Terminated | II | >Gynecologic [GY] | Ovarian |
| NRG-LU004 | Phase I Trial of Accelerated or Conventionally Fractionated Radiotherapy Combined With MEDI4736 (durvalumab) in PD-L1 High Locally Advanced Non-Small Cell Lung Cancer (NSCLC) (ARCHON-1) | Closed to Accrual | I | >Lung [LU] | Other |
| RTOG-0815 | A Phase III Prospective Randomized Trial of Dose-Escalated Radiotherapy with or without Short-Term Androgen Deprivation Therapy for Patients with Intermediate-Risk Prostate Cancer | Closed to Accrual | III | >Genitourinary [GU] | Prostate |
| NRG-CC007CD | Increasing the Dose of Survivorship Care Planning in Prostate Cancer Survivors Who Receive Androgen Deprivation Therapy | Closed to Accrual | II | >Cancer Care Delivery Research [CD] | Other |
| NRG-HN004 | Randomized Phase II/III Trial of Radiotherapy with Concurrent MEDI4736 (Durvalumab) vs. Radiotherapy with Concurrent Cetuximab in Patients with Locoregionally Advanced Head and Neck Cancer with a Contraindication to Cisplatin | Closed to Accrual & Treatment | II/III | >Head and Neck [HN] | Head and Neck |
| COG-NRG ARST1321 | Pazopanib Neoadjuvant Trial in Non-Rhabdomyosarcoma Soft Tissue Sarcomas (PAZNTIS): A Phase II/III Randomized Trial of Preoperative Chemoradiation or Preoperative Radiation Plus or Minus Pazopanib (NSC#737754; IND#118613) | Closed to Accrual | II/III | >Other [DT] | Sarcoma |
| NRG-BR004 | A Randomized, Double-Blind, Phase III Trial of Taxane/Trastuzumab/Pertuzumab with Atezolizumab or Placebo in First-Line HER2-Positive Metastatic Breast Cancer | Closed to Accrual | III | >Breast [BR] | Breast |
| GOG-0213 | A Phase III Randomized Controlled Clinical Trial Of Carboplatin and Paclitaxel or Gemcitabine) Alone or in Combination with Bevacizumab (NSC #704865, IND #113912) Followed by Bevacizumab and Secondary Cytoreductive Surgery in Platinum-Sensitive, Recurrenovarian, Peritoneal Primary and Fallopian Tube Cancer. NCI-Supplied Agents: Bevacizumab (NSC #704865, IND #113912) | Closed to Accrual | III | >Gynecologic [GY] | Ovarian |
| NRG-GI006 | Phase III Randomized Trial of Proton Beam Therapy (PBT) Versus Intensity Modulated Photon Radiotherapy (IMRT) for the Treatment of Esophageal Cancer | Open to Accrual | III | >Gastrointestinal [GI] | Esophageal |
| RTOG-0926 | A Phase II Protocol for Patients with Stage T1 Bladder Cancer to Evaluate Selective Bladder Preserving Treatment by Radiation Therapy Concurrent with Radiosensitizing Chemotherapy Following a Thorough Transurethral Surgical Re-Staging | Closed to Accrual | II | >Genitourinary [GU] | Bladder |
| NSABP B-39 RTOG 0413 | A Randomized Phase III Study of Conventional Whole Breast Irradiation (WBI) Versus Partial Breast Irradiation (PBI) for Women with Stage 0, I, or II Breast Cancer | Terminated | III | >Breast [BR] | Breast |
| NSABP B-40 | A Randomized Phase III Trial of Neoadjuvant Therapy in Patients with Palpable and Operable Breast Cancer Evaluating the Effect on Pathologic Complete Response (pCR) of Adding Capecitabine or Gemcitabine to Docetaxel when Administered Before AC with or without Bevacizumab and Correlative Science Studies Attempting to Identify Predictors of High Likelihood for pCR with Each of the Regimens | Terminated | III | >Breast [BR] | Breast |
| NRG-GY006 | A Randomized Phase III Trial of Radiation Therapy and Cisplatin Alone or in Combination with Intravenous Triapine in Women with Newly Diagnosed Bulky Stage IB2, Stage II, IIIB, or IVA Cancer of the Uterine Cervix or Stage II-IVA Vaginal Cancer | Closed to Accrual | III | >Gynecologic [GY] | Cervix |
| NRG-GY005 | A Randomized Phase II/III study of the combination of Cediranib and Olaparib compared to Cediranib or Olaparib alone, or Standard of care chemotherapy in women with recurrent platinum-resistant or -refractory ovarian, fallopian tube, or primary peritoneal cancer (COCOS). | Closed to Accrual | II/III | >Gynecologic [GY] | Ovarian |
| NRG-GY004 | A Phase III Study Comparing Single-Agent Olaparib or the Combination of Cediranib and Olaparib to Standard Platinum-Based Chemotherapy in Women with Recurrent Platinum-Sensitive Ovarian, Fallopian Tube, or Primary Peritoneal Cancer | Closed to Accrual | III | >Gynecologic [GY] | Ovarian |
| GOG-0239 | A Phase II Trial of AZD6244 (NSC #748727, IND #77782) in Women with Recurrent Low-Grade Serous Carcinoma of the Ovary or Peritoneum | Terminated | II | >Gynecologic [GY] | Ovarian |
| NRG-BN002 | Phase I Study of Ipilimumab, Nivolumab, and the Combination in Patients With Newly Diagnosed Glioblastoma | Terminated | I | >Brain [BN] | Malignant Glioma |
| NRG-GU005 | Phase III IGRT and SBRT versus IGRT and Hypofractionated IMRT for Localized Intermediate Risk Prostate Cancer | Closed to Accrual | III | >Genitourinary [GU] | Prostate |
| NRG-LU001 | Randomized Phase II Trial of Concurrent Chemoradiotherapy +/- Metformin HCL in Locally Advanced NSCLC | Closed to Accrual | II | >Lung [LU] | Other |
| RTOG-1106 | RTOG 1106/ACRIN 6697, Randomized Phase II Trial of Individualized Adaptive Radiotherapy Using During-Treatment FDG-PET/CT and Modern Technology in Locally Advanced Non-Small Cell Lung Cancer (NSCLC) | Terminated | II | >Lung [LU] | Other |
| NRG-HN001 | Randomized Phase II and Phase III Studies of Individualized Treatment for Nasopharyngeal Carcinoma Based on Biomarker Epstein Barr Virus (EBV) Deoxyribonucleic Acid (DNA) | Open to Accrual | II/III | >Head and Neck [HN] | Head and Neck |
| GOG-0278 | Evaluation of Physical Function and Quality of Life (QOL) Before and After Non-Radical Surgical Therapy (Extra Fascial Hysterectomy or Cone Biopsy with Pelvic Lymphadenectomy) for Stage IA1 (LVSI+) and IA2-IB1 (</= 2 cm) Cervical Cancer | Closed to Accrual | I/II | >Gynecologic [GY] | Cervix |
| RTOG-1122 | Phase II Double-Blinded Placebo-Controlled Study of Bevacizumab With or Without AMG 386 in Patients With Recurrent Glioblastoma or Gliosarcoma | Terminated | II | >Brain [BN] | Other |
| NRG-GY017 | Anti PD-L1 (Atezolizumab) as an Immune Primer and Concurrently with Extended Field Chemoradiotherapy for Node Positive Locally Advanced Cervical Cancer | Closed to Accrual | I | >Gynecologic [GY] | Cervix |
| RTOG-1308 | Phase III Randomized Trial Comparing Overall Survival After Photon Versus Proton Chemoradiotherapy for Inoperable Stage II-IIIB NSCLC | Open to Accrual | III | >Lung [LU] | Other |
| NRG-GI003 | A Phase III Randomized Trial of Protons Versus Photons for Hepatocellular Carcinoma | Open to Accrual | III | >Gastrointestinal [GI] | Liver |
| NRG-BN003 | Phase III Trial of Observation Versus Irradiation for a Gross Totally Resected Grade II Meningioma | Open to Accrual | III | >Brain [BN] | Benign Brain Tumors |
| NRG-BN005 | A Phase II Randomized Trial of Proton vs. Photon Therapy (IMRT) for Cognitive Preservation in Patients with IDH Mutant, Low to Intermediate Grade Gliomas. | Open to Accrual | II | >Brain [BN] | Lower Grade Glioma |
| NRG-HN003 | A Phase I and Expansion Cohort Study of Adjuvant Cisplatin, Intensity-Modulated Radiotherapy, and MK-3475 (Pembrolizumab) in High-Risk Head and Neck Squamous Cell Carcinoma (HNSCC) | Terminated | I | >Head and Neck [HN] | Head and Neck |
| RTOG-0233 | A Phase II Randomized Trial for Patients With Muscle-Invading Bladder Cancer Evaluating Transurethral Surgery and BID Irradiation Plus Either Paclitaxel and Cisplatin or 5-Fluorouracil and Cisplatin Followed by Selective Bladder Preservation and Gemcitabi | Terminated | II | >Genitourinary [GU] | Bladder |
| NRG-GY003 | A Phase II Randomized Trial of Nivolumab with or without Ipilimumab in Patients with Persistent or Recurrent Epithelial Ovarian, Primary Peritoneal or Fallopian Tube Cancer | Closed to Accrual | II | >Gynecologic [GY] | Ovarian |
| NRG-GI002 | A Phase II Clinical Trial Platform of Sensitization Utilizing Total Neoadjuvant Therapy (TNT) in Rectal Cancer | Closed to Accrual | II | >Gastrointestinal [GI] | Anal Canal |
| AGCT1531 | A Phase 3 Study of Active Surveillance for Low Risk and a Randomized Trial of Carboplatin vs. Cisplatin for Standard Risk Pediatric and Adult Patients with Germ Cell Tumors | Open to Accrual | III | >Gynecologic [GY] | Other |
| NRG-GY008 | A Phase II Evaluation of Copanlisib BAY 80-6946 IND #130822, A Selective Inhibitor of PI3KCA, in patients with Persistent or Recurrent Endometrial Carcinoma Harboring PIK3CA Hotspot Mutations | Terminated | II | >Gynecologic [GY] | Uterine Corpus |
| RTOG-0627 | Phase II Trial of Dasatinib in Patients with Recurrent Glioblastoma Multiforme | Terminated | II | >Brain [BN] | Other |
| NRG-GY002 | A Phase II Evaluation of Nivolumab, a Fully Human Antibody against PD-1, in the Treatment of Persistent or Recurrent Cervical Cancer | Terminated | II | >Gynecologic [GY] | Cervix |
| NRG-BR002 | A Phase IIR/III Trial of Standard of Care Therapy with or without Stereotactic Body Radiotherapy (SBRT) and/or Surgical Ablation for Newly Oligometastatic Breast Cancer | Closed to Accrual | II/III | >Breast [BR] | Breast |
| RTOG-1114 | Phase II Randomized Study of Rituximab, Methotrexate, Procarbazine, Vincristine, and Cytarabine With and Without Low-Dose Whole-Brain Radiotherapy for Primary Central Nervous System Lymphoma | Terminated | II | >Brain [BN] | Other |
| GOG-0225 | Can Diet and Physical Activity Modulate Ovarian or Primary Peritoneal Cancer Progression-Free Survival? | Closed to Accrual | III | >Gynecologic [GY] | Ovarian |
| NRG-GY009 | A Randomized, Phase II/III Study of Pegylated Liposomal Doxorubicin and CTEP-Supplied Atezolizumab (IND #134427) Versus Pegylated Liposomal Doxorubicin, CTEP-Supplied Bevacizumab and CTEP-Supplied Atezolizumab Versus Pegylated Liposomal Doxorubicin and CTEP-Supplied Bevacizumab in Platinum Resistant Ovarian Cancer | Closed to Accrual | II/III | >Gynecologic [GY] | Ovarian |
| NSABP BP-59 | Bone Marrow Analysis in Early-Stage Breast Cancer | Terminated | III | >Breast [BR] | Breast |
| NSABP B-37 IBCSG 27-02 | A Randomized Clinical Trial of Adjuvant Chemotherapy for Radically Resected Loco-Regional Relapse of Breast Cancer | Terminated | III | >Breast [BR] | Breast |
| RTOG-0522 | A Randomized Phase III Trial of Concurrent Accelerated Radiation and Cisplatin versus Concurrent Accelerated Radiation, Cisplatin, and Cetuximab C225 [Followed by Surgery for Selected Patients] for Stage III and IV Head and Neck Carcinomas | Terminated | III | >Head and Neck [HN] | Head and Neck |
| RTOG-9601 | A Phase III Trial of Radiation Therapy with or without Casodex in Patients with PSA Elevation Following Radical Prostatectomy for pT3N0 Carcinoma of the Prostate | Terminated | III | >Genitourinary [GU] | Prostate |
| RTOG-0232 | A Phase III Study Comparing Combined External Beam Radiation And Transperineal Interstitial Permanent Brachytherapy With Brachytherapy Alone For Selected Patients With Intermediate Risk Prostatic Carcinoma | Terminated | III | >Genitourinary [GU] | Prostate |
| RTOG-0828 | Pilot Project to Reduce Missing RTOG Quality of Life Data Via Electronic Web-Based Form Collection: A Companion Study for RTOG 0415 (A Phase III Randomized Study of Hypofractionated 3D-CRT/IMRT Versus Conventionally Fractionated 3D-CRT/IMRT in Patients wi | Closed to Accrual | III | >Genitourinary [GU] | Prostate |
| GOG-0186H | A Randomized Phase II Evaluation of Weekly Paclitaxel (NSC# 673089) versus Weekly Paclitaxel with Oncolytic Reovirus (Reolysin NSC # 729968, BB-IND #13370) in the Treatment of Recurrent or Persistent Ovarian, Fallopian Tube or Primary Peritoneal Cancer | Terminated | II | >Gynecologic [GY] | Ovarian |
| RTOG-1115 | Phase III Trial of Dose Escalated Radiation Therapy and Standard Androgen Deprivation Therapy (ADT) with a GnRH Agonist vs. Dose Escalated Radiation Therapy and Enhanced ADT with a GnRH Agonist and TAK-700 for Men with High Risk Prostate Cancer | Closed to Accrual | III | >Genitourinary [GU] | Prostate |
| RTOG-0834 | Phase III Trial on Concurrent and Adjuvant Temozolomide Chemotherapy in Non-1p/19q Deleted Anaplastic Glioma: The CATNON Intergroup Trial | Closed to Accrual | III | >Brain [BN] | Benign Brain Tumors |
| NRG-GI001 | Randomized Phase III Study of Focal Radiation Therapy for Unresectable, Localized Intrahepatic Cholangiocarcinoma | Terminated | III | >Gastrointestinal [GI] | Liver |
| RTOG-9110 | NCCTG 86-72-51: A Phase III Evaluation of Postoperative Radiation in Low Grade Intracranial Astrocytomas and Oligodendrogliomas | Closed to Accrual | III | >Brain [BN] | Other |
| RTOG-0621 | Adjuvant 3DCRT/IMRT in Combination with Androgen Suppression and Docetaxel for High Risk Prostate Cancer Patients Post-Prostatectomy: A Phase II Trial | Terminated | II | >Genitourinary [GU] | Other |
| RTOG-9408 | A Phase III Trial of the Study of Endocrine Therapy used as a Cytoreductive and Cytostatic Agent Prior to Radiation Therapy in Good Prognosis Locally Confined Adenocarcinoma of the Prostate | Terminated | III | >Genitourinary [GU] | Prostate |
| RTOG-0630 | A Phase II Trial of Image Guided Preoperative Radiotherapy for Primary Soft Tissue Sarcomas of the Extremity | Terminated | II | >Other [DT] | Sarcoma |
| RTOG-1203 | A Randomized Phase III Study Of Standard Vs. IMRT Pelvic Radiation For Post-Operative Treatment Of Endometrial And Cervical Cancer (TIME-C)--RTOG CCOP Study | Terminated | III | >Gynecologic [GY] | Other |
| RTOG-0129 | A Phase III Trial of Concurrent Radiation and Chemotherapy (Followed by Surgery for Residual Primary/N2-3 Nodal Disease) for Advanced Head and Neck Carcinomas | Terminated | III | >Head and Neck [HN] | Head and Neck |
| RTOG-1306 | A Randomized Phase II Study of Individualized Combined Modality Therapy for Stage III Non-Small Cell Lung Cancer (NSCLC) | Terminated | II | >Lung [LU] | Other |
| RTOG-0848 | A Phase IIR and a Phase III Trial Evaluating Both Erlotinib (Ph IIR) And Chemoradiation (Ph III) As Adjuvant Treatment For Patients With Resected Head Of Pancreas Adenocarcinoma | Closed to Accrual | II/III | >Gastrointestinal [GI] | Pancreas |
| RTOG-9402 | Phase III Intergroup Randomized Comparison of Radiation Alone Vs Pre-Radiation Chemotherapy for Pure and Mixed Anaplastic Oligodendrogliomas | Terminated | III | >Brain [BN] | Other |
| RTOG-0915 | A Randomized Phase II Study Comparing 2 Stereotactic Body Radiation Therapy (SBRT) Schedules for Medically Inoperable Patients with Stage I Peripheral Non-Small Cell Lung Cancer | Terminated | II | >Lung [LU] | Small Cell |
| RTOG-0618 | A Phase II Trial of Stereotactic Body Radiation Therapy (SBRT) in the Treatment of Patients with Operable Stage I/II Non-Small Cell Lung Cancer | Terminated | II | >Lung [LU] | Small Cell |
| RTOG-0615 | A Phase II Study of Concurrent Chemoradiotherapy Using Three-Dimensional Conformal Radiotherapy (3D-CRT) or Intensity-Modulated Radiation Therapy (IMRT) + Bevacizumab (BV) For Locally or Regionally Advanced Nasopharyngeal Cancer | Terminated | II | >Head and Neck [HN] | Head and Neck |
| RTOG-0131 | A Phase II Trial of Pre-Irradiation and Concurrent Temozolomide in Patients With Newly Diagnosed Anaplastic Oligodendrogliomas and Mixed Anaplastic Oligoastrocytomas | Terminated | II | >Brain [BN] | CNS Metastatic Disease |
| RTOG-9813 | A Phase III (Phase I Closed) Randomized Study of Radiation Therapy and Temozolomide (IND #60,265) Versus Radiation Therapy and Nitrosourea for Anaplastic Astrocytoma and Mixed Anaplastic Oligoastrocytoma (Astrocytoma Dominant) | Terminated | I/III | >Brain [BN] | Other |
| RTOG-9802 | A Phase II Study of Observation in Favorable Low-Grade Glioma and Phase III Study of Radiation With or Without PCV Chemotherapy in Unfavorable Low-Grade Glioma | Terminated | II/III | >Brain [BN] | Other |
| RTOG-0938 | A Randomized Phase II Trial Of Hypofractionated Radiotherapy For Favorable Risk Prostate Cancer-RTOG CCOP Study | Terminated | II | >Genitourinary [GU] | Prostate |
| RTOG-0813 | Seamless Phase I/II Study of Stereotactic Lung Radiotherapy (SBRT) for Early Stage, Centrally Located, Non-Small Cell Lung Cancer (NSCLC) in Medically Inoperable Patients | Terminated | I/II | >Lung [LU] | Other |
| RTOG-0912 | A Randomized Phase II Study of Concurrent Intensity Modulated Radiation Therapy (IMRT), Paclitaxel and Pazopanib (NSC 737754)/Placebo, for The Treatment of Anaplastic Thyroid Cancer | Terminated | II | >Head and Neck [HN] | Head and Neck |
| RTOG-0415 | A Phase III Randomized Study of Hypofractionated 3DCRT/IMRT versus Conventionally Fractionated 3DCRT/IMRT in Patients Treated for Favorable-Risk Prostate Cancer | Terminated | III | >Genitourinary [GU] | Prostate |
| RTOG-0521 | A Phase III Protocol of Androgen Suppression (AS) and 3DCRT/IMRT Vs. AS and 3DCRT/IMRT Followed by Chemotherapy with Docetaxel and Prednisone for Localized, High-Risk Prostate Cancer | Terminated | III | >Genitourinary [GU] | Prostate |
| RTOG-0524 | A Phase I/II Trial of a Combination of Paclitaxel and Trastuzumab With Daily Irradiation or Paclitaxel Alone With Daily Irradiation Following Transurethral Surgery for Non-Cystectomy Candidates With Muscle-Invasive Bladder | Terminated | I/II | >Genitourinary [GU] | Bladder |
| RTOG-9910 | A Phase III Trial to Evaluate the Duration of Neoadjuvant Total Androgen Suppression (TAS) and Radiation Therapy (RT) in Intermediate-Risk Prostate Cancer | Terminated | III | >Genitourinary [GU] | Prostate |
| RTOG-0837 | Randomized, Phase II, Double-Blind, Placebo-Controlled Trial of Conventional Chemoradiation and Adjuvant Temozolomide Plus Cediranib versus Conventional Chemoradiation and Adjuvant Temozolomide Plus Placebo in Patients with Newly Diagnosed Glioblastoma | Terminated | II | >Brain [BN] | Other |
| RTOG-0631 | Phase II/III Study of Image-Guided Radiosurgery/SBRT for Localized Spine Metastasis | Terminated | II/III | >Symptom Management [CC] | Other |
| RTOG-0617 | A Randomized Phase III Comparison of Standard- Dose (60 Gy) Versus Highdose (74 Gy) Conformal Radiotherapy with Concurrent and Consolidation Carboplatin/Paclitaxel +/- Cetuximab (IND #103444) in Patients with Stage IIIA/IIIB Non-Small Cell Lung Cancer | Terminated | III | >Lung [LU] | Small Cell |
| RTOG-0537 | A Phase II/III Study Comparing Acupuncture-like Transcutaneous Electrical Nerve Stimulation (ALTENS) Versus Pilocarpine in Treating Early Radiation-Induced Xerostomia | Terminated | II/III | >Head and Neck [HN] | Head and Neck |
| RTOG-1016 | Phase III Trial of Radiotherapy Plus Cetuximab Versus Chemoradiotherapy in HPV-Associated Oropharynx Cancer | Closed to Accrual | III | >Head and Neck [HN] | Head and Neck |
| RTOG-0126 | A Phase III Randomized Study of High Dose 3DCRT/IMRT versus Standard Dose 3DCRT/IMRT in Patients Treated for Localized Prostate Cancer | Terminated | III | >Genitourinary [GU] | Prostate |
| RTOG-0526 | A Prospective Phase II Trial of Transperineal Ultrasound-Guided Brachytherapy for Locally Recurrent Prostate Adenocarcinoma Following External Beam Radiotherapy | Terminated | II | >Genitourinary [GU] | Other |
| RTOG-0712 | A Phase II Randomized Study for Patients with Muscle-Invasive Bladder Cancer Evaluating Transurethral Surgery and Concomitant Chemoradiation by Either BID Irradiation plus 5-Fluorouracil and Cisplatin or QD Irradiation plus Gemcitabine Followed by Selective Bladder Preservation and Gemcitabine/Cisplatin Adjuvant Chemotherapy | Terminated | II | >Genitourinary [GU] | Bladder |
| RTOG-0424 | A Phase II Study of a Temozolomide-Based Chemoradiotherapy Regimen for High Risk Low-Grade Gliomas | Terminated | II | >Brain [BN] | Lower Grade Glioma |
| RTOG-0539 | Phase II Trial of Observation for Low-Risk Meningiomas and of Radiotherapy for Intermediate- and High-Risk Meningiomas | Closed to Accrual | II | >Brain [BN] | Other |
| RTOG-0913 | Phase I/II Trial of Concurrent RAD001 (Everolimus) With Temozolomide/Radiation Followed by Adjuvant RAD001/Temozolomide in Newly Diagnosed Glioblastoma | Terminated | I/II | >Brain [BN] | Other |
| RTOG-1014 | A Phase II Study of Repeat Breast Preserving Surgery and 3D-Conformal Partial Breast Re-Irradiation (PBRI) for Local Recurrence of Breast Carcinoma | Terminated | II | >Breast [BR] | Breast |
| RTOG-1205 | Randomized Phase II Trial of Concurrent Bevacizumab and Re-Irradiation Versus Bevacizumab Alone as Treatment for Recurrent Glioblastoma | Terminated | II | >Brain [BN] | Other |
| RTOG-0436 | A Phase III Trial Evaluating the Addition of Cetuximab to Paclitaxel, Cisplatin, and Radiation for Patients With Esophageal Cancer Who Are Treated Without Surgery | Terminated | III | >Gastrointestinal [GI] | Esophageal |
| RTOG-1010 | A Phase III Trial Evaluating the Addition of Trastuzumab to Trimodality Treatment of Her2-Overexpressing Esophageal Adenocarcinoma | Closed to Accrual | III | >Gastrointestinal [GI] | Esophageal |
| RTOG-9804 | Phase III Trial of Observation +/- Tamoxifen vs. RT +/- Tamoxifen for Good Risk Ductal Carcinoma In Situ (DCIS) of the Female Breast | Terminated | III | >Breast [BR] | Breast |
| RTOG-1005 | A Phase III Trial Of Accelerated Whole Breast Irradiation With Hypofractionation Plus Concurrent Boost Versus Standard Whole Breast Irradiation Plus Sequential Boost For Early-Stage Breast Cancer | Closed to Accrual | III | >Breast [BR] | Breast |
| GOG-0263 | Randomized Phase III Clinical Trial of Adjuvant Radiation Versus Chemoradiation in Intermediate Risk, Stage I/IIA, Cervical Cancer Treated with Initial Radical Hysterectomy and Pelvic Lymphdenectomy. | Closed to Accrual | III | >Gynecologic [GY] | Cervix |
| NSABP B-47 | A Randomized Phase III Trial of Adjuvant Therapy Comparing Chemotherapy Alone (Six Cycles of Docetaxel Plus Cyclophosphamide or Four Cycles of Doxorubicin Plus Cyclophosphamide Followed by Weekly Paclitaxel) to Chemotherapy Plus Trastuzumab in Women with Node-Positive or High-Risk Node-Negative HER2-Low Invasive Breast Cancer | Closed to Accrual | III | >Breast [BR] | Breast |
| NRG-GI004/SWOG-S1610 | Colorectal Cancer Metastatic dMMR Immuno-Therapy (COMMIT) Study: A Randomized Phase III Study of mFOLFOX6/Bevacizumab Combination Chemotherapy with or without Atezolizumab or Atezolizumab Monotherapy in the First-Line Treatment of Patients with Deficient DNA Mismatch Repair (dMMR) Metastatic Colorectal Cancer | Open to Accrual | III | >Gastrointestinal [GI] | Colorectal |
| GOG-0281 | A Randomized Phase II/III Study to Assess the Efficacy of Trametinib (GSK 1120212) in Patients with Recurrent or Progressive Low-Grade Serous Ovarian Cancer or Peritoneal Cancer | Closed to Accrual | II/III | >Gynecologic [GY] | Ovarian |
| GOG-9928 | A Phase I study of the safety of intraperitoneal EGEN-001 (IL-12 plasmid formulated with PEG-PEI-Cholesterol lipopolymer) administered in combination with pegylated liposomal doxorubicin (PLD) in recurrent ovarian cancer patients. The purpose of this studtermine the safety of EGEN-001 IP plus PLD treatment in platinum-recurrent ovarian cancer patients. | Terminated | I | >Gynecologic [GY] | Ovarian |
| GOG-9924 | A Phase I Pharmacokinetic Study of Intraperitoneal CTEP-Supplied Agent Bortezomib (PS-341, NSC 681239, IND# 58443) and Carboplatin (NSC# 241240)in Patients with Persistent or Recurrent Ovarian, Fallopian Tube, or Primary Peritoneal Cancer | Terminated | I | >Gynecologic [GY] | Ovarian |
| GOG-0280 | A Phase II Eval of the Poly(ADP-Ribose)Polymerase (PARP)-1 and -2 Inhibitor Veliparib (ABT-888)(NSC #737644) in the tx of Persistent or Recurrent Ovarian, Fallopian Tube or Primary Peritoneal Ca in Patients who carry a germline BRCA 1 or 2 Mutation | Terminated | II | >Gynecologic [GY] | Ovarian |
| RTOG-0920 | A Phase III Study of Postoperative Radiation Therapy (IMRT) +/- Cetuximab for Locally-Advanced Resected Head and Neck Cancer | Closed to Accrual | III | >Head and Neck [HN] | Head and Neck |
| NRG-BR001 | A Phase 1 Study of Stereotactic Body Radiotherapy (SBRT) for the Treatment of Multiple Metastases | Terminated | I | >Breast [BR] | Breast |
| NRG-CC001 | A Randomized Phase III Trial of Memantine and Whole-Brain Radiotherapy With or Without Hippocampal Avoidance in Patients With Brain Metastases | Terminated | III | >Symptom Management [CC] | Other |
| NSABP NCIC CTG MA.32.F | Biobehavioral Mechanisms of Fatigue in Patients Treated on NCIC CTG MA.32: A Phase III Randomized Trial of Metformin Versus Placebo on Recurrence and Survival in Early Stage Breast Cancer | Closed to Accrual | III | >Breast [BR] | Breast |
| NSABP B-52 | A Randomized Phase III Trial Evaluating Pathologic Complete Response Rates in Patients with Hormone Receptor-Positive, HER2-Positive, Large Operable and Locally Advanced Breast Cancer Treated with Neoadjuvant Therapy of Docetaxel, Carboplatin, Trastuzumab, and Pertuzumab (TCHP) With or Without Estrogen Deprivation | Closed to Accrual | III | >Breast [BR] | Breast |
| NSABP B-51 RTOG 1304 | A Randomized Phase III Clinical Trial Evaluating Post-Mastectomy Chestwall and Regional Nodal XRT and Post-Lumpectomy Regional Nodal XRT in Patients with Positive Axillary Nodes Before Neoadjuvant Chemotherapy Who Convert to Pathologically Negative Axillary Nodes After Neoadjuvant Chemotherapy | Closed to Accrual | III | >Breast [BR] | Breast |
| NSABP B-49 | A Phase III Clinical Trial Comparing the Combination of Docetaxel Plus Cyclophosphamide to Anthracycline-Based Chemotherapy Regimens for Women with Node-Positive or High-Risk Node-Negative, HER2-Negative Breast Cancer | Closed to Accrual | III | >Breast [BR] | Breast |
| NSABP B-43 | A Phase III Clinical Trial Comparing Trastuzumab Given Concurrently with Radiation Therapy and Radiation Therapy Alone for Women with HER2-Positive Ductal Carcinoma In Situ Resected by Lumpectomy | Closed to Accrual | III | >Breast [BR] | Breast |
| NSABP B-42 | A Clinical Trial to Determine the Efficacy of Five Years of Letrozole Compared to Placebo in Patients Completing Five Years of Hormonal Therapy Consisting of an Aromatase Inhibitor (AI) or Tamoxifen Followed by an AI in Prolonging Disease-Free Survival in Postmenopausal Women with Hormone Receptor Positive Breast Cancer | Closed to Accrual | III | >Breast [BR] | Breast |
| NRG-BR003 | A Randomized Phase III Trial of Adjuvant Therapy Comparing Doxorubicin Plus Cyclophosphamide Followed by Weekly Paclitaxel with or without Carboplatin for Node-Positive or High-Risk Node-Negative Triple-Negative Invasive Breast Cancer | Closed to Accrual | III | >Breast [BR] | Breast |
| NRG-GY011 | A Randomized Surgical Window Pilot Investigation of the Relationship of Short Term Medroxyprogesterone Acetate (NSC #26386) Compared to Medroxyprogesterone Acetate Plus Entinostat (NSC #706995) on the Morphologic, Biochemical, and Molecular Changes in Primary Endometrioid Adenocarcinoma of the Uterine Corpus | Terminated | I | >Gynecologic [GY] | Uterine Corpus |
| NRG-HN002 | A Randomized Phase II Trial for Patients with p16 Positive, Non-Smoking Associated, Locoregionally Advanced Oropharyngeal Cancer | Closed to Accrual | II | >Head and Neck [HN] | Head and Neck |
| GOG-0286B | A Randomized Phase II/III Study of Paclitaxel/Carboplatin/Metformin (NSC#91485) Versus Paclitaxel/Carboplatin/Placebo as Initial Therapy for Measurable Stage III or IVA, Stage IVB, or Recurrent Endometrial Cancer | Closed to Accrual | II/III | >Gynecologic [GY] | Uterine Corpus |
| RTOG-1008 | A Randomized Phase II/Phase III Study of Adjuvant Concurrent Radiation and Chemotherapy versus Radiation Alone in Resected High-Risk Malignant Salivary Gland Tumors | Closed to Accrual & Treatment | II/III | >Head and Neck [HN] | Head and Neck |
| RTOG-0839 | Randomized Phase II Study of Pre-Operative Chemoradiotherapy +/- Panitumumab (IND #110152) Followed By Consolidation Chemotherapy In Potentially Operable Locally Advanced (Stage IIIA, N2+) Non-Small Cell Lung Cancer | Terminated | II | >Lung [LU] | Other |
| RTOG-0724 | Phase III Randomized Study of Concurrent Chemotherapy and Pelvic Radiation Therapy with or without Adjuvant Chemotherapy in High-Risk Patients with Early-Stage Cervical Carcinoma Following Radical Hysterectomy | Closed to Accrual | III | >Gynecologic [GY] | Ovarian |
| GOG-0229O | A randomized phase II study with a phase I lead-in to assess the antitumor efficacy of the MEK inhibitor Trametinib alone or in combination with GSK2141795, an AKT inhibitor in patients with recurrent or persistent endometrial cancer. | Terminated | II | >Gynecologic [GY] | Uterine Corpus |
| RTOG-1216 | Randomized Phase II/III Trial of Adjuvant Radiation Therapy with Cisplatin, Docetaxel-Cetuximab, or Cisplatin-Atezolizumab in Pathologic High-Risk Squamous Cell Cancer of the Head and Neck | Open to Accrual | II/III | >Head and Neck [HN] | Head and Neck |
| GOG-0209 | A Randomized Phase III Trial of Doxorubicin/Cisplatin/Paclitaxel and G-CSF versus Carboplatin/Paclitaxel in Patients with Stage III & IV or Recurrent Endometrial Cancer | Terminated | III | >Gynecologic [GY] | Uterine Corpus |
| GOG-0275 | A phase III randomized trial of pulse actinomycin-d versus multi-day methotrexate for the treatment of low-risk gestational trophoblastic neoplasia | Terminated | III | >Gynecologic [GY] | Other |
| GOG-0273 | Chemotherapy toxicity in elderly women with ovarian, primary peritoneal or fallopian tube cancer | Terminated | III | >Gynecologic [GY] | Ovarian |
| GOG-0261 | A Randomized Phase III Trial of Paclitaxel Plus Carboplatin Versus Ifosfamide Plus Paclitaxel in Chemotherapy-Naïve Patients with Newly Diagnosed Stage I-IV, Persistent or Recurrent Carcinosarcoma (Mixed Mesodermal Tumors) of the Uterus or Ovary | Terminated | III | >Gynecologic [GY] | Uterine Corpus |
| GOG-0258 | A randomized phase III trial of cisplatin and tumor volume directed irradiation followed by carboplatin and paclitaxel vs. Carboplatin and paclitaxel for optimally debulked, advanced endometrial carcinoma | Closed to Accrual | III | >Gynecologic [GY] | Uterine Corpus |
| GOG-0252 | A Phase III Clinical Trial of Bevacizumab with IV versus IP Chemotherapy in Ovarian, Fallopian Tube and Primary Peritoneal Carcinoma NCI-Supplied Agent(s): Bevacizumab | Terminated | III | >Gynecologic [GY] | Ovarian |
| GOG-0249 | A phase III trial of pelvic radiation therapy versus vaginal cuff brachytherapy followed by paclitaxel/carboplatin chemotherapy in patients with high risk, early stage endometrial carcinoma | Terminated | III | >Gynecologic [GY] | Uterine Corpus |
| GOG-0241 | A GCIG intergroup multicenter phase III trial of open label carboplatin and paclitaxel +/- NCI-supplied agent: bevacizumab (nsc #704865, ind #113912) compared with oxaliplatin and capecitabine +/- bevacizumab as first line chemotherapy in patients with mucinous epithelial ovarian or fallopian tube cancer (MEOC) | Terminated | III | >Gynecologic [GY] | Ovarian |