NRG-CC008, also known as the SOROCk Trial, is a clinical trial available to a particular group of women with inherited BRCA1 mutations. For these pre-menopausal women, the study is testing whether removal of just the fallopian tubes, with the plan to remove the ovaries at a later time, can reduce the risk of ovarian cancer to the same degree as the usual standard of care of removing both the ovaries and fallopian tubes. Surgical removal of both ovaries and fallopian tubes very effectively reduces the risk of ovarian cancer in most women. Researchers believe that most “ovarian” cancers first begin in the fallopian tubes, suggesting that removing only the fallopian tubes may be as good as removing both the fallopian tubes and ovaries in preventing the development of ovarian cancer, while avoiding surgically induced menopause. This has never been formally tested in a clinical trial. The study will also look at how women on the study feel about their quality of life.
More information about this particular study is located on ClinicalTrials.gov
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Additional information for the NRG-CC008 ‘SOROCk’ trial can be found in the Patient Study Brochure
Below, you can find FAQs about clinical research and this particular clinical trial.
Who is this study for?
What is this study examining?
Doctors and researchers conduct a clinical study, also called a “clinical trial”, to find better ways to prevent, diagnose, or treat an illness. NRG Oncology is supported by the National Cancer Institute and runs clinical studies specifically for patients with cancer or to prevent cancer. Most clinical studies test something we know against something we don’t know. In all situations, these studies are strictly evaluated before they are allowed to be offered to any patient. The study is designed to answer the question that we do not know the answer to, so that current and future patients may have better treatments or information than what we currently have. There are different types of clinical studies that might be available for patients. For more information see “Types of Clinical Trials” and “Phases of Clinical Trials”.
At NRG Oncology, we focus on conducting clinical studies aimed to improve current cancer care practices and the lives of cancer patients. NRG Oncology partners with more than 1,300 member sites world-wide to research ways to improve treatment standards in the cancer community. Our organization is supported primarily through grants from the National Cancer Institute (NCI) and is one of five research groups in the NCI's National Clinical Trial's Network.