NRG-LU006 is a clinical trial studying whether adding a certain type of radiotherapy called IMPRINT in addition to surgery and the standard chemotherapy treatment can help to extend the life of people with malignant pleural mesothelioma (MPM). MPM is a tumor of the tissue that lines the surface of the lungs. Standard treatment includes a pleurectomy/decortication which is surgery to remove the malignant mesothelioma along with the pleura which is the lung lining followed by the chemotherapy drugs pemetrexed and cisplatin (or carboplatin). Researchers want to know if IMPRINT, which is a technique that targets radiation treatment directly to the pleura, in addition to surgery and the chemotherapy drugs pemetrexed and cisplatin (or carboplatin) will be as good as or better than the usual treatment of the same surgery plus the same chemotherapy alone (without IMPRINT).
Before, during, and following treatment, you will be asked to fill out 2 forms with questions about your physical and emotional well-being. Researchers will use this information to learn more about how your cancer and cancer treatment affects people with MPM. If you agree to take part in this study, you will also have the opportunity to participate in optional sample collections for use of your blood and tumor samples in possible future research studies. An additional sample of tumor tissue from your previous biopsy or surgery and blood samples will be collected if you choose to participate in the sample collection. Researchers use these samples to help them learn more about your cancer, using blood and tissue to find new ways to prevent, detect, treat, or cure cancer.
More information about this particular study is located on ClinicalTrials.gov
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Additional information for the NRG Oncology LU006 trial can be found in the Patient Study Brochure
Below, you can find FAQs about clinical research and this particular clinical trial.
Doctors and researchers conduct a clinical study, also called a “clinical trial”, to find better ways to prevent, diagnose, or treat an illness. NRG Oncology is supported by the National Cancer Institute and runs clinical studies specifically for patients with cancer or to prevent cancer. Most clinical studies test something we know against something we don’t know. In all situations, these studies are strictly evaluated before they are allowed to be offered to any patient. The study is designed to answer the question that we do not know the answer to, so that current and future patients may have better treatments or information than what we currently have. There are different types of clinical studies that might be available for patients. For more information see “Types of Clinical Trials” and “Phases of Clinical Trials”.
At NRG Oncology, we focus on conducting clinical studies aimed to improve current cancer care practices and the lives of cancer patients. NRG Oncology partners with more than 1,300 member sites world-wide to research ways to improve treatment standards in the cancer community. Our organization is supported primarily through grants from the National Cancer Institute (NCI) and is one of five research groups in the NCI's National Clinical Trial's Network.