April 12 2022

FORTE (Five- or Ten-Year Colonoscopy for 1-2 Non-Advanced Adenomatous Polyps)( NCT05080673)

VisionTree and NRG-CC005/FORTE

Missing data are a significant problem, particularly for quality-of-life (QOL) assessments. Unlike data for traditional endpoints, such as survival, QOL data can never be obtained retrospectively if it is not provided by the participants at the appropriate time point. This limits researchers’ ability to accurately perform QOL statistical analyses and negatively impacts the clinical relevance of this effort. Typically, QOL forms are filled out in hardcopy (paper). To provide a more convenient method of completing participant-completed questionnaires NRG Oncology is working with VisionTree Software, Inc., San Diego, CA.

VisionTree has developed a tool, VisionTree Optimal Care (VTOC), a HIPAA-secure, user friendly, web-based software system. VisionTree offers participants on this study the option of completing the baseline questionnaires from any location that has a device with Internet access, including the participant’s home, and provides reminders to participants to complete the assessments.

Although the use of the VisionTree tool is strongly preferred and encouraged, participants may complete paper questionnaires. If paper questionnaires are used, the data is manually entered into Rave by site staff.

Administration of the baseline questionnaires

All participants enrolled in CC005 who read or understand English, or Spanish must be asked to complete the Participant-Completed Questionnaires related to demographics, family history, health, diet, and lifestyle factors. The one-time baseline Participant-Completed Questionnaires will be completed and submitted within 30 days after the participant has been randomized on the study.

VTOC Information and Instructions

  • VTOC Webinar Training Series (schedule and registration) and FAQs for research associates
  • Protocol Section 11.2 Optional Online Completion of Participant-Completed Questionnaires
  • Protocol Section 11.3 Administration of CC005 Participant-Completed Questionnaires


For data entry and submission questions contact the CC005 Data Manager, Izabela Frak, NRG Statistics and Data Management Center, at

If you have other questions about the trial, please contact the Clinical Coordinating Department (CCD) at or 800-477-7227. 

Stay current with science. Sign up for our newsletter.

Support NRG Oncology.
Help Our Cause.

We are a leading protocol organizations within the National Clinical Trials Network and we seek to improve the lives of cancer patients by conducting practice-changing, multi-institutional clinical and translational research. Learn More

Donate Today

NRG Oncology Foundation, Inc, is a nonprofit, tax-exempt foundation. Donations to NRG Oncology help us conduct this important mission, and are tax-deductible to the extent permitted by law.