About This Study

FORTE study is led by NRG Oncology and is a part of the National Clinical Trials Network (NCTN) program, which is sponsored by the National Cancer Institute (NCI).

FORTE is a colorectal cancer prevention study looking to determine how often participants who have had 1-2 small benign polyps removed during colonoscopy from their colon otherwise known as adenomatous polyps or adenomas should have repeat surveillance colonoscopies. The primary goal of FORTE is to compare the colorectal cancer rates between the two study groups (repeat colonoscopy at 5 and 10 years versus repeat colonoscopy at 10 years) to see if the rates are equivalent. If they are equivalent, then people in the future would likely be recommended to only undergo a 10-year exam and the 5-year exam may not be necessary. Participants will be asked to donate blood and stool samples and will be followed annually. 

More information about this particular study is located on ClinicalTrials.gov (coming soon)


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Quick Information

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Are you interested in joining this study?

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Want more information?

 

Additional information for the 

NRG Oncology CC005 "FORTE" trial can be found in the Patient Study Brochure

Download Brochure

Educational information on colorectal cancer, screening, prevention, causes and treatment. Can be found on the National Cancer Institute Website – Colorectal Cancer Patient Version.

National Cancer Institute Website

Am I eligible for this study?

People fifty to seventy years of age with a first-time diagnosis of 1-2 non-advanced polyps removed by colonoscopy are eligible to participate in FORTE. The goal is to enroll 9,500 participants: 4,750 in the 5 and 10 year colonoscopy follow up group and 4,750 in the 10 year colonoscopy group.

Your healthcare team is the best source for information about your healthcare options, including the ability to help you make the decision to participate in cancer prevention clinical trials. Be sure to take the information you find to your doctor for discussion about possible studies and for questions and concerns.


Are there other studies I might be eligible for?

Please talk to your healthcare team to see if there are other clinical studies that you may be a good fit for. Click here if you would like to view a more detailed chart of other studies available (coming soon).

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NRG-CC005 FAQ

People who have had 1-2 small benign polyps (non-cancerous tissue growths) removed from their colon.
FORTE study is trying to determine the most efficacious surveillance colonoscopy timing.
The usual approach for patients who are not in a study and who have had 1-2 benign polyps removed is to have a repeat colonoscopy in 5 to 10 years.
If you choose to take part in this study, there is a risk that you could develop colorectal cancer during the study. This could happen in either of the study groups to which you may be assigned. It is not known if the risk of colorectal cancer is reduced in people who have a colonoscopy at 5 and 10 years compared to 10 years There is a risk you could develop colorectal cancer whether you participate in the study.

There are risks to having more frequent colonoscopy exams. The following are possible unexpected complications of having a colonoscopy. These risks could occur whether or not you are participating in this study but the likelihood of experiencing these complications may increase with more frequent colonoscopy exams.

  • Belly pain
  • Bleeding in the large bowel
  • Complications due to anesthesia, including problems with your heart or breathing
  • Hole in the large bowel or rectum, possibly requiring surgery
It is not possible to know now whether a repeat colonoscopy exam at 10 years will prevent colorectal cancer as well as a repeat colonoscopy at 5 years and 10 years.  This study will help doctors learn to better help people in the future.
Your participation in the primary aim of the study will end after you undergo the colonoscopy exam at 10 years and the information about your 10-year colonoscopy is obtained from your medical records. You will be contacted for up to 30 years after you join the study. Your doctors may also be contacted for up to 30 years after you join the study to obtain copies of your colonoscopy reports or medical records. Contacts after your colonoscopy exam at 10 years will be used to obtain long-term medical information and outcomes. The contact for up to 30 years is to allow long-term follow-up of your medical outcomes.
No. Taking part in this study is voluntary. You are free to choose to participate or not to participate. If you choose to participate in this study, you can leave the study at any time.
You and/or your insurance company will need to pay for the costs of the medical care you get as a part of the study, which includes the colonoscopy exams, just as you would if you were not participating in the study. You will not be paid to take part in this study.

Before you decide to be in the study, you should check with your health plan or insurance company to find out exactly what they will pay for.
If you decide not to take part in this study, your doctor will discuss other surveillance colonoscopy options with you.
Your privacy is very important to the study researchers and biobank. They will make every effort to protect it. Here are just a few of the steps they will take: They will remove identifiers, such as your initials, from your sample and information.

  • They will replace them with a code number. There will be a master list linking the code numbers to names, but they will keep it separate from the samples and information.
  • Researchers who study your sample and information will not know who you are. They also must agree that they will not try to find out who you are.
  • Your personal information will not be given to anyone unless it is required by law.
  • If research results are published, your name and other personal information will not be used.

Clinical Studies FAQ

Doctors and researchers conduct a clinical study, also called a “clinical trial”, to find better ways to prevent, diagnose, or treat an illness. NRG Oncology is supported by the National Cancer Institute and runs clinical studies specifically for patients with cancer or to prevent cancer. Most clinical studies test something we know against something we don’t know. In all situations, these studies are strictly evaluated before they are allowed to be offered to any patient. The study is designed to answer the question that we do not know the answer to, so that current and future patients may have better treatments or information than what we currently have. There are different types of clinical studies that might be available for patients. For more information see “Types of Clinical Trials” and “Phases of Clinical Trials”. 


Patients who volunteer to take part in a clinical study are followed closely by their health care professionals and members of the research team. For more information see “Research Team Members”.
Yes. They are exactly the same thing.
The care cancer doctors provide to cancer patients today is the direct result of clinical studies (also known as clinical trials) that were done in the past. Clinical studies give doctors and the treatment team information about what types of treatments work and what treatments do not work, in a number of different situations. Some studies focus on treating the cancer, others on preventing the cancer, and others on helping patients feel better or healthier during or after treatments. When you take part in a clinical study, you add to our knowledge about cancer and it may help improve cancer care for future patients. Clinical studies are available to patients with many types of cancer and at all stages of treatment. In some situations, the only way to get these new treatments is by joining a clinical study.
A clinical study may take place in many locations, such as:

  • physician offices
  • hospitals
  • clinics


  • A study is typically led by a principal investigator who is a doctor or other advanced health care professional. A clinical study is carried out by following a very specific plan known as the “protocol”. The protocol is designed so all patients in the study are treated as well as possible and in the same way. The protocol also provides rules for the doctors and clinical study staff to follow to keep patients safe and make sure the study is run in an ethical manner.
    No, not at all. Participation in a clinical study is completely voluntary. For more information see “Deciding to Take Part in a Clinical Trial”. You are free to choose to participate or not to participate. If you choose to participate in a study, you may still decide to leave the study at any time. If you decide not to participate in a study, your doctor will discuss other treatment options with you. For more information see “Questions to Ask Your Doctor about Treatment Clinical Trials".

    If you decide not to take part in a clinical study, you still have other choices. Talk to your doctor about your other choices.For example:

    • You may choose to have the usual treatment approach (known as “standard of care”)
    • You may choose to take part or learn more about a different study, if one is available
    • You may choose not to be treated for cancer

    About NRG Oncology

    At NRG Oncology, we focus on conducting clinical studies aimed to improve current cancer care practices and the lives of cancer patients. NRG Oncology partners with more than 1,300 member sites world-wide to research ways to improve treatment standards in the cancer community. Our organization is supported primarily through grants from the National Cancer Institute (NCI) and is one of five research groups in the NCI's National Clinical Trial's Network.

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