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Beryl McCormick MD
Closed to Accrual
In the defined good-risk group, assess the role of whole breast radiation plus/minus tamoxifen compared to wide excision to negative margins alone plus/minus tamoxifen, in decreasing or delaying the appearance of local failure, both invasive and in situ, and preventing the need for mastectomy.
Women >= 26 years of age. Unicentric mammographically detected DCIS. The DCIS must be detected by mammogram or detected as an "incidental" finding after a biopsy is performed for a benign histology (eg, fibroadenoma). Lesions <= 2.5 cm in greatest dimension on mammogram or pathologic specimen; use the largest measured size from the pathology report to obtain the required measurement of <= 2.5 cm. Lesions must be classified as low or intermediate grade DCIS. Inked margins >= 3 mm
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