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Paul Brown MD
Symptom Management [CC]
To determine whether the addition of HA-WBRT increases time to neurocognitive failure at months 2, 4, 6 and 12 as measured by neurocognitive decline on a battery of tests: the Hopkins Verbal Learning Test-Revised (HVLT-R) for Total Recall, Delayed Recall, and Delayed Recognition, Controlled Oral Word Association (COWA), and the Trail Making Test (TMT) Parts A and B.
Pathologically (histologically or cytologically) proven diagnosis of solid tumor malignancy within 5 years prior to registration. Patients may have had prior therapy for brain metastasis, including radiosurgery and surgical resection. Patients must have completed prior therapy by at least 14 days prior to registration for surgical resection and 7 days for radiosurgery.
The following NRG-CC001 form and form instructions are to be printed out and the form completed by the patient on paper. Once complete,the form must be entered electronically in Medidata Rave.
Patient History Form Instructions
NRG-CC001 A5 Standard Patient History Form
Pill Diary- Extended Release
Pill Diary- Twice Daily
NRG-CC001 Neurocognitive Letter
NRG-CC001 Certification Worksheet
NRG-CC001USA (English) EQ-5D-5L
NRG-CC001 Canadian (English) EQ-5D-5L
NRG-CC001 Canadian (French) EQ-5D-5L
Specimen Transmittal Form
NRG-CC001 ST Form
Neurocognitive Assessment Packets
NRG-CC001 Neurocognitive Assessment Packets 1-5(English)
NRG-CC001 Neurocognitive Assessment Packets 1-5 (French)
NRG-CC001 Rave SOC Form
No Objection Letter, amendment 2-3
Clinical Trial Site Information Form, amendment 2-3
Research Ethics Board Approval Form
Qualified Investigator Undertaking Form
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