NRG-BN012 is a clinical study for people who are planning to receive surgery to treat cancer that has spread to your brain, called brain metastases. Currently, patients with brain metastases receive surgery followed by radiation to the site of cancer in your brain. Researchers want to see if giving radiation before surgery, instead of after surgery, can improve the length of time without the cancer in your brain returning, worsening, or causing scarring in your brain.
The type of radiation that patients will receive on NRG-BN012 is called stereotactic radiosurgery (SRS). SRS delivers a high dose of radiation only to the small areas of cancer in the brain and avoids the surrounding normal brain tissue. But the study approach could also cause side effects. This study will help the study doctors find out if this different approach is better than the usual approach.
More information about this particular study is located on ClinicalTrials.gov
If you are age 18 or older and are planning to receive surgery for cancer that has spread to your brain, you may be able to participate. Your healthcare team is the best source for information about your treatment options, including cancer clinical trials. Be sure to take this information to your doctor to discuss your questions and concerns in general and specific to the NRG-BN012 study.
Are you interested in joining the study? Find a participating location
Additional information for the NRG-BN012 study can be found in the Patient Study Brochure. Download Brochure
Below, you can find FAQs about clinical research and this particular clinical trial.
If you decide to take part in the study, you will be assigned to one of two possible study groups. Half the participants will be in one group and half in the second group. Participants in both groups will get a type of radiation called stereotactic radiosurgery (SRS). SRS delivers a high dose of radiation only to the small areas of cancer in the brain and avoids the surrounding normal brain tissue.
Participants in one group will receive the radiation treatment after surgery to remove one of the sites of cancer (usual approach).
Participants assigned to the second group will receive the radiation treatments before surgery (study approach).
Talk to your insurance provider and make sure that you understand what your insurance pays for and what it doesn’t pay for if you take part in this clinical trial. Also, find out if you need approval from your plan before you can take part in the study.
You will not be paid for taking part in this study.
Doctors and researchers conduct a clinical study, also called a “clinical trial,” to find better ways to prevent, diagnose, or treat an illness. NRG Oncology is supported by the National Cancer Institute (NCI) and runs clinical studies specifically for patients with cancer or to prevent cancer. Most clinical studies test something we know against something we don’t know. In all situations, these studies are strictly evaluated before they are allowed to be offered to any patient. The study is designed to answer the question that we do not know the answer to, so that current and future patients may have better treatments or information than what we currently have. There are different types of clinical studies that might be available for patients. For more information see “Types of Clinical Trials” and “Phases of Clinical Trials”.
Patients who volunteer to take part in a clinical study are followed closely by their health care professionals and members of the research team. For more information see “Research Team Members”.
At NRG Oncology, we focus on conducting clinical studies aimed to improve current cancer care practices and the lives of cancer patients. NRG Oncology partners with more than 1,300 member sites world-wide to research ways to improve treatment standards in the cancer community. Our organization is supported primarily through grants from the National Cancer Institute (NCI) and is one of five research groups in the NCI's National Clinical Trial's Network.