Head and Neck Cancer Committee

Purpose

The NRG Oncology Head and Neck Cancer Committee’s purpose is to improve the lives of head and neck cancer patients by designing and conducting practice-changing multi-institutional clinical trials and translational research. The Committee supervises numerous Working Groups which act to identify novel scientific advances that are incorporated into our trials, support conduct and completion of our clinical trials and other research activities, and promote further learning and dissemination from our research findings.

This Committee addresses four main types of research: 1. Technological advances in surgery and radiation therapy treatments 2. Biomarkers and biologically driven interventions or treatment approaches 3. Novel types of systemic therapy including targeted therapy and immunotherapy 4. Interventions for special populations including older adults, and chemotherapy-ineligible patients.

The Committee’s goal is to create a future where head and neck cancer patients each have the opportunity for cancer cure and restoration to health and quality of life. We can do this best through developing national and international shared goals and initiatives for the management of head and neck cancers, learning together with our patients from evidence-based standard-setting clinical trials, fostering advancement and development of new therapeutics and translational and biomarker research, educating patients and providers on evolving technologies and treatment approaches, and mentoring the next generation of investigators.

The Committee meets monthly, including twice per year in person, but the Committee’s numerous Working Groups meet more frequently.

Head and Neck Cancer Committee Leadership

Chair

Sue Yom, MD PhD

Vice Chair

Neil Hayes, MD

Vice Chair

Chris Holsinger, MD

Vice Chair

Trisha Wise-Draper, MD, PhD

Working Groups

Head and Neck Translational Working Group

Chair

Neil Hayes

Vice Chair

Sidharth Puram

H&N Surgery Working Group

Chair

Christopher Holsinger

H&N Skin Working Group

Chair

Shlomo Koyfman

Vice Chair

Christopher Barker

H&N Rare Tumor Working Group

Chair

Richard Bakst

Vice Chair

Stephen Lai

Previously Untreated Locally Advanced Working Group

Chair

Trisha Wise-Draper

Vice Chair

James Bates

H&N PRO-CE Working Group

Chair

Steven Chang

Vice Chair

Minh Tam Truong

H&N Recurrent-Metastatic Working Group

Chair

Dwight Heron

Vice Chair

Anna Spreafico

Core Committee Members
  • Musaddiq Awan
  • Julie Bauman
  • Dukagjin Blakaj
  • Scott V. Bratman
  • Jimmy Caudell
  • Bhisham Chera
  • Jennifer H. Choe
  • Christine Chung
  • John De Almeida
  • Neal Dunlap
  • Thomas Galloway
  • Neil Hayes
  • Christina Henson
  • Chris Holsinger
  • Jed Katzel
  • Jamie Ku
  • Stephen Lai
  • Nancy Lee
  • Mihir Patel
  • Sidharth V. Puram
  • Shyam S.D. Rao
  • James William Rocco
  • Cristina Rodriguez
  • Nabil Saba
  • Michael A. Samuels
  • Nicole C. Schmitt
  • David Schwartz
  • Jeffrey Shoop
  • Heath Skinner
  • Paul L. Swiecicki
  • Vinita Takiar
  • Samantha Tam
  • Horatio Thomas
  • John Waldron
  • Trisha Wise-Draper
  • Sue Yom
General Committee Members
  • Nishant Agrawal
  • Carryn Anderson
  • Jennifer L. Anderson
  • Anthony J. Apicelli, III
  • Hani Ashamalla
  • Vilija Avizonis
  • Musaddiq Awan
  • Samar Azawi
  • Richard Bakst
  • Sujith Baliga
  • Brittany Barber
  • Christopher A. Barker
  • James E. Bates
  • Beth M. Beadle
  • Aashish Bhatt
  • Mihir K. Bhayani
  • Andrew C. Birkeland
  • Alec Block
  • Christopher L. Brett
  • David Brizel
  • Shauna Campbell
  • Daniel R. Carrizosa
  • Mark Chambers
  • Douglas  Chepeha
  • Jennifer H. Choe
  • Karen Y. Choi
  • Farshad N. Chowdhury
  • Francisco J. Civantos
  • David A. Clump
  • Kevin J. Contrera
  • Pippa F. Cosper
  • Jennifer Cracchiolo
  • Roi Dagan
  • Rushil R. Dang
  • Jennifer F. De Los Santos
  • Virginia Diavolitsis
  • Jennifer A. Dorth
  • Umamaheswar Duvvuri
  • Heather A. Edwards
  • Kyle S. Ettinger
  • Daniel Faden
  • Carole Fakhry
  • Janice L. Farlow
  • Rocco M. Ferrandino
  • Robert L. Ferris
  • David W.A. Forner
  • Catherine H. Frenkel
  • Christopher Fundakowski
  • Muhammad Furqan
  • Gregory Gan
  • Ian Ganly
  • Madhur K. Garg
  • Adam A. Garsa
  • Jessica Geiger
  • Michael F. Gensheimer
  • Maged Ghaly
  • Laila A. Gharzai
  • Michael Gibson
  • Maura L. Gillison
  • Emile Gogineni
  • Evan M. Graboyes
  • Jennifer H. Gross
  • Neil Gross
  • Craig Eli Grossman
  • Alexander N. Hanania
  • Richard A. Harbison
  • Catherine T. Haring
  • Molly E. Heft- Neal
  • Dwight Heron
  • Colin Hill
  • Ryan T. Hughes
  • Katherine A. Hutcheson
  • Sachin R. Jhawar
  • Chris Jones
  • Richard Jordan
  • Nikhil Joshi
  • Aditya Juloori
  • Anne C. Kane
  • Hyunseok Kang
  • Jung Julie Kang
  • Sana Karam
  • Vidhya Karivedu
  • Rohan R. Katipally
  • Saad Khan
  • Ana Kiess
  • Randall Kimple
  • Kedar Shirish Kirtane
  • Julie Kish
  • Tim Kruser
  • Jay J. Liao
  • Miriam N. Lango
  • Ryan M. Lanning
  • Anh H. Le
  • Steve  Lee
  • Anna Lee
  • David Y. Lee
  • Gary D. Lewis
  • Christopher Lominska
  • Bridgette Ma
  • Daniel Ma
  • Sung Jun Ma
  • Sean S. Mahase
  • Rafael Manon
  • Emily J. Marchiano
  • Charles Mayo
  • Christopher McLaughlin
  • Michelle Mierzwa
  • Jacob A. Miller
  • Dominic Moon
  • Luc G.T. Morris
  • Wojciech K. Mydlarz
  • David Neskey
  • Phuc Felix Nguyen-Tan
  • Matthew Old
  • Aru Panwar
  • Henry S. Park
  • Krupal Patel
  • Mihir R. Patel
  • Rusha Patel
  • Cesar Perez
  • Minh Phan
  • Katharine Price
  • Sidharth V. Puram
  • Krishna Rao
  • Mohammad Razaq
  • Niema B. Razavian
  • Jeremy Richmon
  • Fahad Rind
  • Jared Robbins
  • Dylan F. Roden
  • David M Routman
  • Soumon Rudra
  • Zeyad Sako
  • Michael Samuels
  • Vlad C. Sandulache
  • Philip E. Schaner
  • Nicole C. Schmitt
  • Christopher Schultz
  • David  Schwartz
  • Geroge Shenouda
  • David J. Sher
  • Eric Sherman
  • Siddharth H. Sheth
  • Lauren C. Shih
  • Aditya Varnam Shreenivas
  • Monica E. Shukla
  • Kulbir Sidhu
  • Andrew Sikora
  • Anurag Singh
  • Guy Slonimsky
  • Matthew E. Spector
  • Anna Spreafico
  • William A. Stokes
  • Erich Sturgis
  • Rathan M. Subramaniam
  • Baran D. Sumer
  • Fangdi Sun
  • John  Sunwoo
  • Krithika Suresh
  • Samantha Tam
  • Sewit Teckie
  • Theodoros N. Teknos
  • Carissa M. Thomas
  • Toms Vengaloor Thomas
  • Wade Thorstad
  • Michael C. Topf
  • Melanie E. Townsend
  • Jillian Tsai
  • Varun Vendra
  • Matthew C. Ward
  • Garrett T. Wasp
  • Maurice Willis
  • Stuart Wong
  • Canhua Xiao
  • George Q. Yang
  • Justine Yang Bruce
  • Min Yao
  • Sun K. Yi
  • Melissa R. Young
  • Mehran Yusuf
  • Mark E. Zafereo
  • Kaveh Zakeri
  • Dan Zandberg
  • Anthony Zeitouni
  • Joseph Zenga
  • Jose P. Zevallos
  • Simeng Zhu
  • Zachary S. Zumsteg
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Study Title Status Phase Disease Category Disease Site
NRG-CC013

A Randomized, Masked, Placebo Controlled, Phase II Trial Of Concurrent Chemoradiation With BMX-001 In Patients With Head And Neck Squamous Cell Carcinoma Receiving Concurrent Chemoradiation

Open to Accrual II Head and Neck [HN] Other
NRG-HN001

Randomized Phase II and Phase III Studies of Individualized Treatment for Nasopharyngeal Carcinoma Based on Biomarker Epstein Barr Virus (EBV) Deoxyribonucleic Acid (DNA)

Closed to Accrual & Treatment II/III Head and Neck [HN] Head and Neck
NRG-HN002

A Randomized Phase II Trial for Patients with p16 Positive, Non-Smoking Associated, Locoregionally Advanced Oropharyngeal Cancer

Terminated II Head and Neck [HN] Head and Neck
NRG-HN003

A Phase I and Expansion Cohort Study of Adjuvant Cisplatin, Intensity-Modulated Radiotherapy, and MK-3475 (Pembrolizumab) in High-Risk Head and Neck Squamous Cell Carcinoma (HNSCC)

Terminated I Head and Neck [HN] Head and Neck
NRG-HN004

Randomized Phase II/III Trial of Radiotherapy with Concurrent MEDI4736 (Durvalumab) vs. Radiotherapy with Concurrent Cetuximab in Patients with Locoregionally Advanced Head and Neck Cancer with a Contraindication to Cisplatin

Terminated II/III Head and Neck [HN] Head and Neck
NRG-HN005

A Randomized Phase II/III Trial of De-Intensified Radiation Therapy for Patients with Early-Stage, P16-Positive, Non-Smoking Associated Oropharyngeal Cancer

Closed to Accrual & Treatment II/III Head and Neck [HN] Head and Neck
NRG-HN006

Randomized Phase II/III Trial of Sentinel Lymph Node Biopsy Versus Elective Neck Dissection for Early-Stage Oral Cavity Cancer

Open to Accrual II/III Head and Neck [HN] Head and Neck
NRG-HN007

An Open-Label, Phase III Study of Platinum-Gemcitabine with or Without Nivolumab in the First-Line Treatment of Recurrent or Metastatic Nasopharyngeal Carcinoma

Terminated III Head and Neck [HN] Head and Neck
NRG-HN008

Phase I Trial with Expansion Cohort of DNA-PK Inhibition and IMRT in Cisplatin-Ineligible Patients with Stage 3-4 Local-Regionally Advanced Head and Neck Squamous Cell Carcinoma (HNSCC)

Closed to Accrual & Treatment I Head and Neck [HN] Head and Neck
NRG-HN009

Randomized Phase II/III Trial of Radiation with Cisplatin at 100 mg/m2 Every Three Weeks Versus Radiation with Weekly Cisplatin at 40 mg/m2 for Patients with Locoregionally Advanced Squamous Cell Carcinoma of the Head and Neck (SCCHN)

Temporarily Closed to Accrual II/III Head and Neck [HN] Head and Neck
NRG-HN010

A Phase II Trial of HER2-Targeted Therapies for Recurrent, Metastatic, or Unresectable HER2-Expressing Salivary Gland Cancers

Open to Accrual II Head and Neck [HN] Head and Neck
NRG-HN011

A Randomized Phase II Study of Nivolumab Versus Nivolumab and BMS-986016 (Relatlimab) as Maintenance Treatment After First-Line Treatment with Platinum-Gemcitabine-Nivolumab for Patients with Epstein-Barr Virus-Associated Recurrent/Metastatic Nasopharyngeal Carcinoma (REMAIN)

Open to Accrual II Head and Neck [HN] Head and Neck
NRG-HN014

Randomized Phase III Trial of Neoadjuvant Immunotherapy with Response-Adapted Treatment Versus Standard-of-Care Treatment for Resectable Stage III/IV Cutaneous Squamous Cell Carcinoma (C-PRE)

Open to Accrual III Head and Neck [HN] Other
NRG-HN015

A Phase II Randomized Trial of Neoadjuvant Chemotherapy or Chemo-Immunotherapy in Patients with Recurrent/Persistent PD-L1 Enriched Squamous Cell Carcinoma of the Head and Neck Undergoing Salvage Surgery (NEOPOLIS)

Open to Accrual II Head and Neck [HN] Other
RTOG-0129

A Phase III Trial of Concurrent Radiation and Chemotherapy (Followed by Surgery for Residual Primary/N2-3 Nodal Disease) for Advanced Head and Neck Carcinomas

Terminated III Head and Neck [HN] Head and Neck
RTOG-0522

A Randomized Phase III Trial of Concurrent Accelerated Radiation and Cisplatin versus Concurrent Accelerated Radiation, Cisplatin, and Cetuximab C225 [Followed by Surgery for Selected Patients] for Stage III and IV Head and Neck Carcinomas

Terminated III Head and Neck [HN] Head and Neck
RTOG-0537

A Phase II/III Study Comparing Acupuncture-like Transcutaneous Electrical Nerve Stimulation (ALTENS) Versus Pilocarpine in Treating Early Radiation-Induced Xerostomia

Terminated II/III Head and Neck [HN] Head and Neck
RTOG-0615

A Phase II Study of Concurrent Chemoradiotherapy Using Three-Dimensional Conformal Radiotherapy (3D-CRT) or Intensity-Modulated Radiation Therapy (IMRT) + Bevacizumab (BV) For Locally or Regionally Advanced Nasopharyngeal Cancer

Terminated II Head and Neck [HN] Head and Neck
RTOG-0912

A Randomized Phase II Study of Concurrent Intensity Modulated Radiation Therapy (IMRT), Paclitaxel and Pazopanib (NSC 737754)/Placebo, for the Treatment of Anaplastic Thyroid Cancer

Terminated II Head and Neck [HN] Head and Neck
RTOG-0920

A Phase III Study of Postoperative Radiation Therapy (IMRT) +/- Cetuximab for Locally-Advanced Resected Head and Neck Cancer

Closed to Accrual & Treatment III Head and Neck [HN] Head and Neck
RTOG-1008

A Randomized Phase II / Phase III Study of Adjuvant Concurrent Radiation and Chemotherapy Versus Radiation Alone in Resected High-Risk Malignant Salivary Gland Tumors

Closed to Accrual & Treatment II/III Head and Neck [HN] Head and Neck
RTOG-1016

Phase III Trial of Radiotherapy Plus Cetuximab Versus Chemoradiotherapy in HPV-Associated Oropharynx Cancer

Terminated III Head and Neck [HN] Head and Neck
RTOG-1216

Randomized Phase II/III Trial of Adjuvant Radiation Therapy with Cisplatin, Docetaxel-Cetuximab, or Cisplatin-Atezolizumab in Pathologic High-Risk Squamous Cell Cancer of the Head and Neck

Open to Accrual II/III Head and Neck [HN] Head and Neck

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