Genitourinary Cancer Committee

Purpose

The mission of the NRG Genitourinary Cancer Committee is to improve the lives of patients with prostate, bladder, and renal cancers by designing and conducting practice-changing multi-institutional clinical trials, and by performing translational research that supports biomarker-driven personalization of care. We seek strategies that can improve cancer outcomes and/or enhance patient quality of life, and are committed to providing a forum where leaders in the GU oncology community can work closely together while helping to develop the next generation of leaders in the field. The Committee meets monthly, including twice per year in person at the NRG semi-annual meetings.

Genitourinary Cancer Committee Leadership

Chair

Paul L. Nguyen, MD

Vice Chair

Todd Morgan

Vice Chair

Phuoc Tho Tran

Vice Chair

Rana McKay, MD

Working Groups

Upfront Treatments for Prostate Cancer

Chair

Daniel Spratt

Post-operative Treatments for Prostate Cancer

Chair

William Hall

Bladder Cancer Therapy

Jason

Efstathiou

Renal Cancer Therapy

Chair

Rana McKay

New Investigator Working Group

Chair

Paul Nguyen

Translational Science GU Cancer

Chair

Phuoc Tran, MD, PhD

Core Committee Members
  • Jean Paul Bahary
  • Leslie Ballas
  • Brian Baumann
  • Ale Berlin
  • Tom Boike
  • Mark Buyyounski
  • Ron Chen
  • Deb Citrin
  • Paul Crispen
  • Scott Delacroix
  • Neil Desai
  • Dayssy Alexandra Diaz-Pardo
  • Tanya Dorff
  • Jason Efstathiou
  • Rod Ellis
  • Hiram Gay
  • Bill Hall
  • Dan Hamstra
  • Andrea Hartszark
  • Karen Hoffman
  • I-Chow Joe Hsu
  • Ashesh Jani
  • Sophia Kamran
  • Rojano Kashani
  • Paul P. Koffer
  • Bridget Koontz
  • Dan Krauss
  • Colleen Lawton
  • Daniel J. Lee
  • Jeffrey Lee
  • Robert W. Lee
  • Stanley Liauw
  • Himu Lukka
  • Ravi Madan
  • David Marshall
  • Rana McKay
  • Cynthia Menard
  • Dror Michaelson
  • Jeff Michalski
  • David Miyamoto
  • Osama Mohamad
  • Shalini Moningi
  • Scott Morgan
  • Todd Morgan
  • Alicia Morgans
  • Himanshu Nagar
  • Thomas Ng
  • Adam Olson
  • J. Daniel Pennington
  • Allan Pollack
  • Ed Posadas
  • Alan Dal Pra
  • Adam Raben
  • Dana Rathkopf
  • Mack Roach
  • Seth Rosenthal
  • Ashley Ross
  • Sean Sachdev
  • Howard Sandler
  • Oliver Sartor
  • Tyler Seibert
  • Xinglei Shen
  • Jeff Simko
  • Abhishek Solanki
  • Daniel Y Song
  • Catherine S. Spina
  • Dan Spratt
  • Chad Tang
  • Phuoc Tho Tran
  • Richard Valicenti
  • Neha Vapiwala
  • Robert Wallace
  • Zach Zumsteg
General Committee Members
  • Matthew C. Abramowitz
  • Adanma Anji
  • Hani Ashamalla
  • Ayanambakkam Attanathi
  • K.C. Balaji
  • Alex Balogh
  • Pedro Barata
  • Rhonda Bitting
  • Matthew J. Boyer
  • Anna M. Brown
  • Deborah Bruner
  • Arnab Chakravarti
  • Albert Chang
  • Jonathan Chatzkel
  • Richard Choo
  • Hans Chung
  • John Coen
  • Mark Corkum
  • Brett Cox
  • Brian Cross
  • Douglas Dahl
  • Robert Den
  • Israel Deutsch
  • Vishal R Dhere
  • Marie Duclos
  • Libni Eapen
  • Michael R. Folkert
  • Aurelie Garant
  • Jun Gong
  • Sheela Hanasoge
  • Raquibul Hannan
  • Alan Hartford
  • Comron J. Hassanzadeh
  • Eric Horwitz
  • Andrew J. Huang
  • K. Saad Jahangir
  • Vikram Jairam
  • Bagi Jana
  • James R. Janopaul-Naylor
  • Skyler B. Johnson
  • Gavin P. Jones
  • Arash Rezazadeh Kalebasty
  • Austin Kirschner
  • Amar U. Kishan
  • Christien A. Kluwe
  • Lawrence Koutcher
  • Timothy Kuzel
  • Christopher Luminais
  • Timothy D. Malouff
  • Malcolm Mattes
  • Michael J. McCormack, Jr.
  • Neil Mendhiratta
  • Anoop Meraney
  • Joseph A. Miccio
  • Mark V. Mishra
  • Timur Mitin
  • Gerard Morton
  • Brian Myre
  • Anthony T. Nguyen
  • Krishnan Patel
  • Ravi Patel
  • Sagar A. Patel
  • Houng Pham
  • Ryan M. Phillips
  • Luke Pike
  • Thomas Pisansky
  • Allan Pollack
  • Thomas Pugh
  • Rubina Qamar
  • Anne W. Rajkumar
  • Srinivas Raman
  • Brian Ramnaraign
  • Zachery R. Reichert
  • Tyler Robin
  • George Rodrigues
  • Nikhil T. Sebastian
  • Michael Seider
  • Steven Seyedin
  • Daniel Shasha
  • Jay C. Shiao
  • William Shipley
  • Timothy Showalter
  • Luis Souhami
  • Shivani Sud
  • Robin Toton
  • Alfredo I Urdaneta
  • Bhanu Prasad Venkatesulu
  • Eric Vigneault
  • Melinda Weiblen
  • Michael J. Whalen
  • Jessica M. Wilson
  • Daniel X. Yang
  • James Yu
  • Nicholas Zaorsky
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Study Title Status Phase Disease Category Disease Site
EA8185

ECOG-ACRIN/NRG Joint Study:A Study of Chemotherapy and Radiation Therapy Compared to Chemotherapy and Radiation Therapy Plus MEDI4736 (Durvalumab) Immunotherapy for Bladder Cancer Which Has Spread to the Lymph Nodes, the INSPIRE Study

Closed to Accrual II Genitourinary [GU] Bladder
NRG-GU001

Randomized Phase II Trial of Postoperative Adjuvant IMRT Following Cystectomy for pT3/pT4 Urothelial Bladder Cancer

Closed to Accrual II Genitourinary [GU] Bladder
NRG-GU002

Phase II-III Trial of Adjuvant Radiotherapy and Androgen Deprivation Following Radical Prostatectomy with or Without Adjuvant Docetaxel

Closed to Accrual II/III Genitourinary [GU] Prostate
NRG-GU003

A Randomized Phase III Trial of Hypofractionated Post-Prostatectomy Radiation Therapy (HYPORT) Versus Conventional Post-Prostatectomy Radiation Therapy (COPORT)

Terminated III Genitourinary [GU] Prostate
NRG-GU005

Phase III IGRT and SBRT Vs IGRT and Hypofractionated IMRT for Localized Intermediate Risk Prostate Cancer

Closed to Accrual & Treatment III Genitourinary [GU] Prostate
NRG-GU006

A Phase II, Double-Blinded, Placebo-Controlled Randomized Trial of Salvage Radiotherapy with or Without Enhanced Anti-Androgen Therapy with Apalutamide in Recurrent Prostate Cancer

Closed to Accrual & Treatment II Genitourinary [GU] Prostate
NRG-GU007

Randomized Phase II Trial of Niraparib with Standard Combination Radiotherapy and Androgen DeprIvation Therapy (ADT) in High Risk Prostate Cancer (with Initial Phase I) (NADIR*)

Complete I/II Genitourinary [GU] Prostate
NRG-GU008

Randomized Phase III Trial Incorporating Apalutamide and Advanced Imaging into Salvage Treatment for Patients with Node-Positive Prostate Cancer After Radical Prostatectomy (INNOVATE*) *INtensifying treatment for NOde positive prostate cancer by VArying the hormonal ThErapy

Closed to Accrual III Genitourinary [GU] Prostate
NRG-GU009

Parallel Phase III Randomized Trials for High Risk Prostate Cancer Evaluating De-Intensification for Lower Genomic Risk and Intensification of Concurrent Therapy for Higher Genomic Risk with Radiation (PREDICT-RT*)

Closed to Accrual III Genitourinary [GU] Prostate
NRG-GU010

Parallel Phase III Randomized Trials of Genomic-Risk Stratified Unfavorable Intermediate Risk Prostate Cancer: De-Intensification And Intensification Clinical Trial Evaluation (GUIDANCE)

Closed to Accrual III Genitourinary [GU] Prostate
NRG-GU011

A Phase II Double-Blinded, Placebo-Controlled Trial of PROstate OligoMETastatic RadiotHErapy with or Without ANdrogen Deprivation Therapy in Oligometastatic Prostate Cancer (NRG Promethean)

Closed to Accrual II Genitourinary [GU] Prostate
NRG-GU012

Randomized Phase II Stereotactic Ablative Radiation Therapy (SABR) for Metastatic Unresected Renal Cell Carcinoma (RCC) Receiving Immunotherapy (SAMURAI)

Open to Accrual II Genitourinary [GU] Other
NRG-GU013

The Phase III ‘High Five Trial’ Five Fraction Radiation For High-Risk Prostate Cancer

Open to Accrual III Genitourinary [GU] Prostate
NRG-GU014

Randomized Phase II Trial of Pembrolizumab and Radiation vs. Radiation and Concurrent Chemotherapy for High-Grade T1 Bladder Cancer (PARRC Trial)

Open to Accrual II Genitourinary [GU] Bladder
NRG-GU015

The Phase III Adaptive Radiation and Chemotherapy for Muscle Invasive Bladder Cancer Trial (ARCHER)

Open to Accrual III Genitourinary [GU] Bladder
RTOG-0126

A Phase III Randomized Study of High Dose 3D-CRT/IMRT Versus Standard Dose 3D-CRT/IMRT in Patients Treated for Localized Prostate Cancer

Terminated III Genitourinary [GU] Prostate
RTOG-0232

A Phase III Study Comparing Combined External Beam Radiation and Transperineal Interstitial Permanent Brachytherapy with Brachytherapy Alone for Selected Patients with Intermediate Risk Prostatic Carcinoma

Terminated III Genitourinary [GU] Prostate
RTOG-0233

A Phase II Randomized Trial for Patients With Muscle-Invading Bladder Cancer Evaluating Transurethral Surgery and BID Irradiation Plus Either Paclitaxel and Cisplatin or 5-Fluorouracil and Cisplatin Followed by Selective Bladder Preservation and Gemcitabi

Terminated II Genitourinary [GU] Bladder
RTOG-0415

A Phase III Randomized Study of Hypofractionated 3D-CRT/IMRT Versus Conventionally Fractionated 3D-CRT/IMRT in Patients with Favorable-Risk Prostate Cancer

Terminated III Genitourinary [GU] Prostate
RTOG-0521

A Phase III Protocol of Androgen Suppression (AS) and 3DCRT/IMRT vs AS and 3DCRT/IMRT Followed by Chemotherapy with Docetaxel and Prednisone for Localized, High-Risk Prostate Cancer

Terminated III Genitourinary [GU] Prostate
RTOG-0524

A Phase I/II Trial of a Combination of Paclitaxel and Trastuzumab With Daily Irradiation or Paclitaxel Alone With Daily Irradiation Following Transurethral Surgery for Non-Cystectomy Candidates With Muscle-Invasive Bladder

Terminated I/II Genitourinary [GU] Bladder
RTOG-0526

A Prospective Phase II Trial of Transperineal Ultrasound-Guided Brachytherapy for Locally Recurrent Prostate Adenocarcinoma Following External Beam Radiotherapy

Terminated II Genitourinary [GU] Other
RTOG-0534

A Phase III Trial of Short Term Androgen Deprivation with Pelvic Lymph Node or Prostate Bed Only Radiotherapy (SPPORT) in Prostate Cancer Patients with a Rising PSA After Radical Prostatectomy

Terminated III Genitourinary [GU] Prostate
RTOG-0621

Adjuvant 3DCRT/IMRT in Combination with Androgen Suppression and Docetaxel for High Risk Prostate Cancer Patients Post-Prostatectomy: A Phase II Trial

Terminated II Genitourinary [GU] Other
RTOG-0712

A Phase II Randomized Study for Patients with Muscle-Invasive Bladder Cancer Evaluating Transurethral Surgery and Concomitant Chemoradiation by Either BID Irradiation Plus 5-Fluorouracil and Cisplatin or QD Irradiation Plus Gemcitabine Followed by Selective Bladder Preservation and Gemcitabine/Cisplatin Adjuvant Chemotherapy

Terminated II Genitourinary [GU] Bladder
RTOG-0815

A Phase III Prospective Randomized Trial of Dose-Escalated Radiotherapy with or without Short-Term Androgen Deprivation Therapy for Patients with Intermediate-Risk Prostate Cancer

Terminated III Genitourinary [GU] Prostate
RTOG-0828

Pilot Project to Reduce Missing RTOG Quality of Life Data Via Electronic Web-Based Form Collection: A Companion Study for RTOG 0415 (A Phase III Randomized Study of Hypofractionated 3D-CRT/IMRT Versus Conventionally Fractionated 3D-CRT/IMRT in Patients wi

Closed to Accrual III Genitourinary [GU] Prostate
RTOG-0924

Androgen Deprivation Therapy and High Dose Radiotherapy with or Without Whole-Pelvic Radiotherapy in Unfavorable Intermediate or Favorable High Risk Prostate Cancer: A Phase III Randomized Trial

Closed to Accrual & Treatment III Genitourinary [GU] Prostate
RTOG-0926

A Phase II Protocol for Patients with Stage T1 Bladder Cancer to Evaluate Selective Bladder Preserving Treatment by Radiation Therapy Concurrent with Radiosensitizing Chemotherapy Following a Thorough Transurethral Surgical Re-Staging

Terminated II Genitourinary [GU] Bladder
RTOG-0938

A Randomized Phase II Trial of Hypofractionated Radiotherapy for Favorable Risk Prostate Cancer

Terminated II Genitourinary [GU] Prostate
RTOG-1115

Phase III Trial of Dose Escalated Radiation Therapy and Standard Androgen Deprivation Therapy (ADT) with a GNRH Agonist vs. Dose Escalated Radiation Therapy and Enhanced ADT with a GNRH Agonist and TAK-700 For Men with High Risk Prostate Cancer

Terminated III Genitourinary [GU] Prostate
RTOG-9408

A Phase III Trial of the Study of Endocrine Therapy used as a Cytoreductive and Cytostatic Agent Prior to Radiation Therapy in Good Prognosis Locally Confined Adenocarcinoma of the Prostate

Terminated III Genitourinary [GU] Prostate
RTOG-9601

A Phase III Trial of Radiation Therapy with or without Casodex in Patients with PSA Elevation Following Radical Prostatectomy for pT3N0 Carcinoma of the Prostate

Terminated III Genitourinary [GU] Prostate
RTOG-9910

A Phase III Trial to Evaluate the Duration of Neoadjuvant Total Androgen Suppression (TAS) and Radiation Therapy (RT) in Intermediate-Risk Prostate Cancer

Terminated III Genitourinary [GU] Prostate
S1806

SWOG/NRG Joint Study: Phase III Randomized Trial of Concurrent Chemoradiotherapy with or without Atezolizumab in Localized Muscle Invasive Bladder Cancer

Closed to Accrual III Genitourinary [GU] Bladder

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