FORTE Study News – December 2025

12/16/2025

FORTE Enrollment Record!

Thanks to the efforts of the national clinical research teams supporting enrollment to NRG-CC005, the FORTE team is excited to report that the trial set a new record of 143 participants in October 2025. We’re in the final sprint to accrue 3800 participants by the end of the year, 40% of total enrollment!

FORTE Site Call – March 12, 2026 – Protocol Compliance 

Join the quarterly FORTE site calls to hear updates on NRG-CC005 and discuss challenges and solutions with other research professionals working to enroll patients to this clinical trial. Registration for these virtual sessions are in these monthly FORTE Fridays broadcasts.

To kick off Colorectal Cancer Awareness Month, the next FORTE Site Call will be on March 12, 2026. FORTE Protocol Chair, Dr. Robert Schoen, will discuss protocol compliance.

NRG Patient Reported Outcomes (PRO) Compliance Officer, Marcie Ritter, presented on compliance at the last FORTE Site Call. Watch the recording on the FORTE | Research Professionals playlist.

Accrual Updates and Milestones (as of December 1, 2025

Top accruing sites:

• Kaiser Permanente – Vallejo – 1895 accrued
• UPMC-Presbyterian Hospital – 351 accrued
• Regions Hospital – 158 accrued

 Most recent randomizations:

• Kaiser Permanente-Vallejo – December 1, 2025
• UPMC-Presbyterian Hospital – December 1, 2025
• Kaiser Permanente-San Marcos – November 26, 2025
• MedStar Georgetown University Hospital – November 26, 2025
• Bay Pines VA Healthcare System – November 26, 2025
• John H Stroger Jr Hospital of Cook County – November 26, 2025
• Park Nicollet Clinic – Saint Louis Park – November 26, 2025

FORTE Top 25 Accruing Sites – December 1, 2025

FORTE Resource Portal

Bookmark this website, that organizes materials found on CTSU: https://www.nrgoncology.org/Clinical-Trials/NRG-CC005/FORTE-Resource-Portal. You will use the same login information used for CTSU to access this page. Once you gain access, the “FORTE Materials for Research Professionals” section contains many materials to assist you with accruing participants. This website also has contact information for questions you may have while working on NRG-CC005.

Find both CIRB-approved and protocol-related documents on CTSU under NRG-CC005.

Do you have new research team members working on NRG-CC005?

Clinical research professionals can sign up for NRG Weekly Broadcasts to receive FORTE Fridays updates directly to your inbox: https://www.nrgoncology.org/Home/News/Weekly-Broadcasts.

Questions from Site Research Staff

If research staff have questions about a patient’s eligibility or study logistics for the NRG-CC005/FORTE Study, contact the Clinical Coordinating Department (CCD) at: FORTE@nrgoncology.org or 1(800) 477-7227.