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Patients
Our Research
Our Research

See our clinical trial portfolio as well as other areas of research conducted by NRG and our publication process.
Our Research Overview
Clinical Trials

Research Resources

Publications & Presentation Resources
The NRG Summer 2025 Semiannual Meeting will be held in person at the Marriott Marquis Hotel in Washington, D.C., from July 24, 2025 – July 26, 2025.
Explore Resources

Search through all available NRG Oncology protocols and available materials.
Find Trials

Research Resources Overview
A compilation of all resources relevant to research conduct or reporting.

Ancillary Projects & Data Sharing
Resources, contact information, applications, and review cycles for ancillary projects and data sharing.

Biospecimen Access
How to request biospecimens collected from patients enrolled on NRG trials (and legacy groups GOG, NSABP, and RTOG).

Data Management Resources
Data Management contact list, compiled resources for sites, and PRO resources.

DMC Charters and Minutes
Data Monitoring Committee (DMC) Panels A, B, and C minutes are password protected (CTEP IAM/ID.me login).

Investigator Resources
Investigator-specific resources or tools to aid in clinical trial participation or conduct.

Quality Assurance (QA) Resources
Information and additional links to resources for NRG’s audit program.

Statistical Reports
NRG trial statistical reports shared at NRG Semiannual Meetings.

Are you presenting on behalf of NRG Oncology? We have templates for presentations and posters for our research here.
Find a Template
Committees
Committees

Our committees are a network of professionals with varying experience that come together to advance NRG’s research.
Committees Overview
Leadership & Committee Openings

Oversight Committees

Disease Specific Committees

NCORP Committees

Non-Disease Specific Committees

Scientific Core Committees

Administrative Committees
NRG Oncology is comprised of several committees and subcommittees that conduct or support NRG trials.
Find a Committee

Check and apply to open membership or leadership positions within our organization.
Check Openings

Oversight Committees Overview
Committees charged with guiding, reviewing, evaluating, and implementing clinical trials in alignment with the NCTN.

Data Monitoring Committee
Reviews the efficacy and morbidity data of trials to ensure decisions regarding these studies are ethically responsible.

Early Phase Trial Oversight Committee
Oversees the group’s Phase I and non-randomized Phase II trials for safety and lead-in components of protocols.

Executive Committee
Comprised of NRG leadership roles and tasked with setting priorities for the group.

Protocol Operations Management
Monitors the progress of activated studies and assesses trial accrual as well as other trial performance metrics.

Research Strategy
Focused on study development and providing feedback or recommendations to disease site and scientific core committees.

Disease Specific Committees Overview
Comprised of 7 committees dedicated to the disease sites most commonly represented in NRG research.

Brain Tumor
Focused on brain tumor research including primary and secondary tumors of the central nervous system.

Breast Cancer
Focused on research aimed at improving the management and outcomes of breast cancer.

Gastrointestinal Cancer
Comprised of colorectal and non-colorectal cancer sectors focused on reducing the burden of GI malignancies for patients.

Genitourinary Cancer
Focused on improving outcomes in GU cancers including prostate, kidney. Bladder, & testicular cancers.

Gynecologic Cancer
Oversees all gynecologic subcommittee cancer research efforts including clinical trial design and translational research.

Head and Neck Cancer
Focused on research aimed at improving the management and outcomes of head & neck cancer.

Lung Cancer
Focused on improving survival and quality of life for patients with non-metastatic lung cancer.

NCORP Committees Overview
NRG NCORP includes committees that improve delivery, disease prevention & control, access & patient quality-of-life.

Cancer Care Delivery Research
Improves clinical outcomes & patient well-being by minimizing factors that may influence care delivery.

Cancer Prevention & Control
Prioritizes interventional studies to improve symptom burden or prevent cancer morbidity.

Health Care Access
Assesses & eliminates differences in health care access to improve cancer care and outcomes.

Patient Centered Outcomes Research
Assesses patient-reported outcomes in therapeutic and cancer control trials.

Non-Disease Specific Committees Overview
Consists of four committees that conduct NRG trials and support research within the disease site committees.

Cancer Care Delivery Research
Improves clinical outcomes & patient well-being by minimizing factors that may influence care delivery.

Cancer Prevention & Control
Prioritizes interventional studies to improve symptom burden or prevent cancer morbidity.

Developmental Therapeutics (DT)
Identifies dose, schedule & preliminary efficacy of novel therapeutic approaches on Phase I & II trials.

Patient Centered Outcomes Research
Assesses patient-reported outcomes in therapeutic and cancer control trials.

Translational Science
Provides translational science expertise to NRG trials & education on new technologies.

Scientific Core Committees Overview
Consists of seven committees that serve as shared resources of expertise and technology for conducting our trials.

Health Care Access (HCA)
Assesses & eliminates differences in health care access to improve cancer care and outcomes.

Imaging
Charged with enhancing the use of imaging on NRG trials and evaluating new novel imaging for trials.

Medical Oncology
Supports systemic treatments used in NRG trials.

Pathology
Assists with the pathology components across disease sites on NRG trials.

Protocol Support
Responsible for overseeing support and quality control of protocol-related activities.

Radiation Oncology
Coordinates NRG’s radiation oncology-related activities for trials.

Surgical Oncology
Focused on providing expertise on NRG trials that require surgical components in treatment.

Administrative Committees Overview
Committees that manage efforts to build engagement, reach, & result reporting for clinical trials & information.

Ancillary Projects
Responsible for the review & conduct of ancillary projects utilizing NRG data.

Communications
Responsible for developing and disseminating content to members & the public regarding NRG trials & efforts.

Investigator & Career Development
Focused on fostering investigator growth and engagement in NRG.

Membership
Responsible for maintaining the process for which NRG members are accepted & operating within the group.

Patient Advocate Committee
Advocates (patients/ caregivers) who partner with our researchers and liaison to their communities regarding research.

Publications
Focused on releasing NRG results in a timely manner via journal publications, presentations, & more.

Gynecologic Cancer Overview
Oversees all gynecologic subcommittee cancer research efforts including clinical trial design and translational research.

Cervix/Vulva Cancer Subcommittee
Part of the GYN cancer committee umbrella. Focused on research pertaining to the cervix or vulva.

Ovarian Cancer Subcommittee
Part of the GYN cancer committee umbrella. Focused on research pertaining to the ovaries.

Rare Tumor Subcommittee
Part of the GYN cancer committee umbrella. Focused on rare cancer types & their biomolecular/genetic abnormalities.

Uterine Corpus Cancer Subcommittee
Part of the GYN cancer committee umbrella. Focused on research pertaining to uterine malignancies.

Developmental Therapeutics (DT) Overview
Identifies dose, schedule & preliminary efficacy of novel therapeutic approaches on Phase I & II trials.

DT Radiation Therapy Subcommittee
Focuses on safety and efficacy of radiotherapy treatments in Phase I & II trials.

DT Gynecologic Phase I Subcommittee
Focuses on safety and efficacy of therapeutics specific to Phase I gynecologic cancers.

Sarcoma Subcommittee
Focuses on research pertaining to or correlating with sarcoma cancers.

Health Care Access (HCA) Overview
Assesses & eliminates differences in health care access to improve cancer care and outcomes.

HCA Committee Events & Announcements
HCA has several events, workshops, symposia & more to with varying topics and learning opportunities.

Imaging Overview
Charged with enhancing the use of imaging on NRG trials and evaluating new novel imaging for trials.

Theranostics Subcommittee
A collaboration of the Imaging & Radiation Oncology Committees for trials that include theranostics.

Medical Oncology Overview
Supports systemic treatments used in NRG trials.

Immunotherapy Subcommittee
Evaluates NRG concepts that utilize immunotherapy.

Pharmacy Subcommittee
Supports NRG trials with pharmacy-specific input including drug information & toxicity management.

Protocol Support Overview
Responsible for overseeing support and quality control of protocol-related activities.

CRA Subcommittee
Advisory subcommittee helping facilitate the goals of the PSC specific to clinical research associates.

CTN Subcommittee
Advisory subcommittee helping facilitate the goals of the PSC specific to clinical trial nurses.

Education & Training Subcommittee
Develops educational programs for CRAs and CTNs in attendance at the NRG Meetings.

Mentorship Subcommittee
Develops and refunds that CRA/CTN Mentorship Program.

Protocol Review Subcommittee
Prospectively reviews protocols & major amendments for barriers & compliance.

Quality Control & Communication Subcommittee
Identifies common audit issues, resolves data issues & distributes content through NRG Communications.

Radiation Oncology Overview
Coordinates NRG’s radiation oncology-related activities for trials.

Medical Physics Subcommittee
Composed of physicists with expertise in the development of technology employed in radiation therapy.

Theranostics Subcommittee
A collaboration of the Imaging & Radiation Oncology Committees for trials that include theranostics.

Investigator & Career Development Overview
Focused on fostering investigator growth and engagement in NRG.

Early Career Mentorship Subcommittee
Committed to the inclusion of early-career investigators through the protocol development process.

Investigator Development Subcommittee
Focused on expanding opportunities & engagement for investigators at all career levels.

Membership Overview
Responsible for maintaining the process for which NRG members are accepted & operating within the group.

Canadian Members Subcommittee
Focused specifically on the accrual & research aims for Canadian sites.

International Members Subcommittee
Focused on accrual & research aims for international institutions.

Veteran Affairs/Military Treatment Facility Subcommittee
Addresses research aims & obstacles specific to veteran and military treatment facilities.
About Us
About Us

NRG conducts multi-institutional phase II & III clinical trials as well as phase I & translational biological studies.
About Us Overview
What is NRG Oncology

Policies and Bylaws

Organizational Overview

Membership

Education & Training

Mentorship Programs

Media & News
Make your voice heard. Join NRG and help us move the needle in cancer research.
Register Here

What is NRG Oncology Overview
Learn more about who we are and what our overarching organizational goals are as an NCI NCTN group.

Scientific Focus
NRG has several scientific aims through our research. Learn more in our scientific focus section.

Legacy Groups
NRG is comprised of three legacy groups. Learn more about our history & the three Foundations.

Support NRG
Learn how you can be a part of our mission to improve outcomes for all impacted by cancer.

Contact Us
Fill out our contact form or find specific contact information by department.

Policies, guidelines, bylaws, and charters pertaining to our organization & research.
View All

Organizational Overview
This overview leads into the many sections and centers that work together under NRG to improve cancer outcomes.

Organizational Structure
See the organizational charts the outline the multiple sections that keep NRG research moving forward.

Operations
These offices help streamline the administrative and protocol development areas of our trials from start to finish.

SDMC
The Statistics and Data Management Center provide expertise for design, conduct, and analysis of NRG trials.

NCORP (Overview & PIs)
NRG’s NCI Community Oncology Research Program brings cancer trials to the community.

Biospecimen Bank
NRG has Biospecimen Banks located in Columbus, Pittsburgh, and San Francisco. Learn more here.

Translational Science
NRG’s translational science program intersects with all NRG clinical trial as well as ancillary projects.

CIRO
The Center for Innovation in Radiation Oncology houses contouring atlases, templates, & tools to conduct research.

Membership Overview
Includes Membership information, related documents or forms, requirements, and other applicable items.

Member Information Form
All members are required to participate in our membership database form even if the response is opting out.

Membership Requirements
Outline of membership categories including associated requirements & responsibilities.

Membership Applications & Roster Forms
Information on how to apply for membership, make changes to your roster & who to contact for questions.

Membership Committee Reviews
This password-protected area includes the content reviewed during Membership Committee meetings twice a year.

Member Institution Lists
All available lists of member sites by type of member, location, CTEP ID, & voting members.

Education & Training Overview
NRG offers educational materials and training courses for a variety of topics relevant to the conduct of our research.

CLASS Learning Modules
Compliance, Learning, and SOP Solutions (CLASS) platform is a learning management system supported by CTSU.

Credentialing & Other Resources
Contact information for RT & Imaging credentialing plus links to other important credentialing or trial resources.

VisionTree Training
VisionTree platform, used on some NRG trials, hosts an NRG-VisionTree training webinar once a month.

Mentorship Programs Overview
NRG is committed to the future of cancer research in all areas and levels of expertise through our mentorship programs.

Health Care Access Fellowship
Health Care Access Fellowship

Early Career Mentored Fellowship Program
NRG selects early-stage investigators via application process to be part of a mentored experience in trial development.

Clinical Research Coordinator Mentor Program
Learn more about our CRC mentorship program and how to become a mentor or mentee.

Media & News Overview
NRG has multiple sources of news including podcasts, newsletters, email broadcasts, and more.

Newsletters
Archive of all NRG Currents newsletter editions. Each edition discusses a wide range of topics.

The NRG Oncology Podcast
The NRG Oncology Podcast is an ongoing streaming podcast with new episodes each month.

Weekly Broadcasts
NRG releases a weekly broadcast each Monday with all important updates on studies and other news.
Meetings

Protocol Documents Tag: rtog 0539

RTOG-0539 Documents

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