RTOG-1005

A Phase III Trial of Accelerated Whole Breast Irradiation with Hypofractionation Plus Concurrent Boost Versus Standard Whole Breast Irradiation Plus Sequential Boost for Early-Stage Breast Cancer

Principal Investigator

Frank A. Vicini

Status

Disease Site

Breast [BR] Breast

Phase

III

Developmental Therapeutics

No

Primary Objective

To determine whether an accelerated course of hypofractionated WBI including a concomitant boost to the tumor bed in 15 fractions following lumpectomy will prove to be non-inferior in local control to a regimen of standard WBI with a sequential boost following lumpectomy for early-stage breast cancer patients. 

 

Patient Population

pStage 0, I, II Breast Cancer resected by lumpectomy

pStage 0, I,II Breast Cancer resected by lumpectomy that followed neoadjuvant systemic therapy

 

Target Accrual

2312