NRG Oncology NCORP solicits PILOT projects addressing NRG NCORP Cancer Care Delivery Research (CCDR) priorities

February 19 2021

Date Issued: February 19, 2021
Submission Due Date: April 30, 2021
Reply to: fielde@nrgoncology.org

Summary

NRG Oncology NCORP solicits PILOT projects addressing NRG NCORP Cancer Care Delivery Research (CCDR) priorities. CCDR is a multidisciplinary science that seeks to improve clinical outcomes and patient well-being by intervening on patient, clinician, and organizational factors that influence cancer care delivery. PILOT projects should generate preliminary data and feasibility assessments to support subsequent CCDR concept development. Specifically, this award will fund work that has high potential to lead to a competitive CCDR concept for review by the NRG and NCI CCDR Steering Committees. Competitive pilot applications address study implementation feasibility and portability to diverse community-based practices.

 CCDR funding priorities are: 
  • Implementation and dissemination interventions related to guideline-based care:  
    • Use of tumor DNA sequencing prior to prescribing targeted therapies;
    • Integrating patient-reported outcomes into clinical practice (extends survival);
    • Enhance access to proven survivorship and palliative care strategies
    • Optimize screening strategies based on disease risk during post-treatment surveillance phase of care
    • Implement symptom management strategies during adjuvant and palliative treatment.
  • Patient-reported outcomes (PROs) related to symptom management: Topics of interest include: 1) use of PRO-CTCAE in NRG NCORP trials, and improving compliance and data capture and 2) employing technology or apps to standardized PRO variables across EHR, registry, and claims data systems. 
  • Interventions to address health disparities among the elderly, racial and ethnic minorities, sexual and gender minorities, and rural residents. 

The committee caps study budgets at $50,000 contingent upon NRG Oncology’s Notice of Award from the Division of Cancer Prevention. The committee may award up to two projects that should commence not later than September 1, 2021 and conclude December 31, 2022.Obligations include submission of a six-month progress report noting completed work to date, and documentation of challenges and opportunities encountered. The CCDR Committee will not issue carry over funds. Principal Investigators are also required to complete progress reports at the end of the project periodPlease solicit your institution's Sponsored Research Office (SRO) to develop the project budget and ensure that the SRO approves the application and budget.  Favorably reviewed projects will require a sub-award agreement with NRG outlining terms and conditions for the host institution. NRG will reimburse funds upon receipt of invoices. NRG will reimburse payments during the first 6 months of the project, then upon favorable progress report review, additional reimbursements will be made for the remainder of the grant period. We will prioritize applications from institutions positioned to waive indirect costs and/or provide cost sharing. The review committee will also prioritize applications from junior investigators advancing an application with a team including qualified mentors. The review committee will also prioritize underrepresented minority investigators submitting applications.

Background

The NCI prioritizes the following conditions when reviewing CCDR concepts and studies (Please refer to the guidance provided by NCI Healthcare Delivery Research Program):

  • a well-articulated primary focus and related scientific question.
    • addresses a contemporary challenge in community oncology practice
    • demonstrated potential to improve clinical outcomes and patient well-being
    • Can be an Interventional or observational study
      • Observational studies must identify intervention targets 
      • Interventional studies must generate evidence of benefit or dissemination of beneficial intervention
  • Opportunity to include an aim addressing the unique needs and circumstances of minority or underserved populations. 

Additionally, the Institute of Medicine (IOM) report, Delivering High-Quality Cancer Care: Charting a New Course for a System in Crisis provides a conceptual framework that informs NRG Oncology’s CCDR program. Thus, the NRG Oncology NCORP seeks pilot projects testing improvements in quality, access, and value-for-money in cancer care delivery.

Instructions for Applicants

Interested investigators should submit a 5-page proposal with all documents included in one pdf to Erica Field (fielde@nrgoncology.org) by 5pm ET, Friday, April 30, 2021. Proposals should include: 

  • A one-page overview of the project, including specific aims
  • Please include a title page (not part of the page limit) that indicates the title of the proposal, the lead investigator and all co investigators to include institutional affiliations and contact information
  • A clear description of how the project will advance a subsequent CCDR concept
  • An outline of requested NRG Oncology resources (i.e. biospecimen materials, statistical support, etc). Any expenses related to these resources should be outlined in the budget
  • One-page letter of support signed with the department chair specifically stating they will or will not wave F&A and cost share [not included in the 5-page limit]
  • Identification of project Investigators and their affiliation
  • A project timeline [not included in the 5-page limit]
  • The PI’s NIH biosketch [not included in the 5-page limit]
  • A paragraph that describes the PI’s and/or team members previous experience with NRG Oncology. If the PI is new to engagement with NRG Oncology, provide a paragraph that describes why the PI would like to be involved in NRG Oncology and how the pilot funds will be used to advance future work within NRG Oncology NCORP [not included in the 5-page limit].
  • A detailed budget [not included in the 5-page limit]
    • Include funds to be paid to NCORP sites for participation, if any

Submit applications to NRG NCORP Administrator:

Erica Field, MPH, MHA
fielde@nrgoncology.org
215-940-8824

Direct scientific questions to NRG NCORP PI and CCDR Chairs: 

Deborah Watkins Bruner, RN, PhD, FAAN              
NCORP PI
deborah.w.bruner@emory.edu

Joan Walker, MD
NCORP PI
Joan-Walker@ouhsc.edu

Mary E. Cooley, PhD, RN, FAAN
CCDR Committee Chair
Mary_Cooley@dfci.harvard.edu

Matthew Hudson, PhD, MPH
CCDR Committee Vice-Chair
Matt.Hudson@prismahealth.org

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