NRG-CC014

Radiation Therapy for High-Risk Asymptomatic Bone Metastases: A Pragmatic Multicenter Randomized Phase 3 Clinical Trial (PREEMPT)

Principal Investigator

Erin Gillespie

Co-Principal Investigator(s)

Jonathan Yang, MD, PhD

Status

Disease Site

Symptom Management [CC] Bone Metastases

Phase

III

Developmental Therapeutics

No

Primary Objective

To determine whether prophylactic radiation
therapy (RT) to high-risk asymptomatic bone metastases decreases the occurrence
of skeletal-related events (SREs), including pathologic fracture, spinal cord
compression, and surgery to bone (not including palliative radiation for pain
only), compared to standard of care (SOC).

Patient Population

Patients with polymetastatic cancer defined as more than 5 sites of radiographically-evident systemic metastatic disease (excluding intracranial disease).

Target Accrual

280