Principal Investigator/Co-Principal Investigator
Minesh Mehta, MD/Vinai Gondi, MD
To determine if dose-escalated and -intensified photon IMRT or proton beam therapy (using a dose-per-fraction escalation with simultaneous integrated boost) with concomitant and adjuvant temozolomide improves overall survival, as compared to standard-dose photon irradiation with concomitant and adjuvant temozolomide.
Histologically proven diagnosis of glioblastoma (WHO grade IV) confirmed by central review prior to step 2 registration. Tumor tissue that is determined by central pathology review prior to step 2 registration to be of sufficient quantity for analysis of MGMT status. The tumor must be located in the supratentorial compartment only (any component involving the brain stem or cerebellum is not allowed).
Please note this trial is available to non-proton centers.
576 randomized patients (288 Group I, 288 Group II)
Activated October 27, 2014
- The protocol and related documents are available at NRG-BN001
- A letter from NCI to insurance providers regarding coverage for proton therapy is available here.
- A slide set overview of this trial is available here.